INT250825

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Context Info
Confidence 0.96
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.06
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joints 1
GAG (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 76 96.00 Very High Very High Very High
Arthritis 30 91.32 High High
rheumatoid arthritis 4 86.72 High High
Pain 10 83.08 Quite High
metalloproteinase 16 54.40 Quite High
Inflammation 14 42.36 Quite Low
cytokine 4 34.84 Quite Low
Analgesic 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 78 96.00 Very High Very High Very High
Arthritis 30 91.32 High High
Rheumatoid Arthritis 4 86.72 High High
Pain 10 83.08 Quite High
INFLAMMATION 16 42.36 Quite Low
Stress 4 34.40 Quite Low
Syndrome 2 31.04 Quite Low
Hyperplasia 6 17.48 Low Low
Injury 10 7.76 Low Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-FGF8 antibody significantly inhibited the degradation of GAG in the FGF8-treated joints by 33% (P = 0.036).
Protein_catabolism (degradation) of GAG in joints
1) Confidence 0.96 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.06 Pain Relevance 0.03
Degradation of S-GAG was detected by intraarticular injection of FGF8 in rats.
Protein_catabolism (Degradation) of GAG
2) Confidence 0.64 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.00 Pain Relevance 0.57

General Comments

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