INT250832

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2008
Negated 5
Speculated 1
Reported most in Body
Documents 1
Total Number 31
Disease Relevance 13.36
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8)
Anatomy Link Frequency
joints 7
fibroblasts 4
knee 4
synovial cells 3
knee joints 2
Fgf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 62 99.92 Very High Very High Very High
Osteoarthritis 1178 99.36 Very High Very High Very High
Arthritis 465 99.28 Very High Very High Very High
Inflammation 217 96.80 Very High Very High Very High
metalloproteinase 248 95.48 Very High Very High Very High
Analgesic 62 91.04 High High
Pain 155 90.08 High High
fibrosis 31 84.84 Quite High
cytokine 62 62.72 Quite High
ketamine 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 62 99.92 Very High Very High Very High
Hyperplasia 93 99.84 Very High Very High Very High
Breast Cancer 31 99.76 Very High Very High Very High
Injury 155 99.52 Very High Very High Very High
Osteoarthritis 1209 99.36 Very High Very High Very High
Arthritis 465 99.28 Very High Very High Very High
Disease 93 97.92 Very High Very High Very High
Synovial Sarcoma 31 95.92 Very High Very High Very High
Pain 155 90.08 High High
INFLAMMATION 248 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the meniscectomized group, FGF8 was expressed on proliferated synovial cells and fibroblasts, but expression of FGF8 was absent or minimal in normal joints.
Neg (absent) Gene_expression (expression) of FGF8 in joints
1) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.31 Pain Relevance 0.12
FGF8 may also be involved in ectopic bone and cartilage formation by breast cancer cells that produce high amounts of FGF8 [20].
Gene_expression (produce) of FGF8 in cartilage associated with breast cancer
2) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.64 Pain Relevance 0.30
These studies suggest that the injury of synovia induces the expression of FGF8 in the joint, and this may promote degradation of cartilage via a paracrine system.
Gene_expression (expression) of FGF8 in joint associated with injury
3) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.82 Pain Relevance 0.22
In the normal group, very weak expression of FGF8 was observed in synovial cells but not in fibroblasts (Figure 1c).
Gene_expression (expression) of FGF8 in fibroblasts
4) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.44 Pain Relevance 0.15
Initially, a rabbit meniscectomy model of OA, in which typical degenerative changes are observed in the operated knee joints [22,23], was used to detect the expression of FGF8.
Gene_expression (expression) of FGF8 in knee joints associated with osteoarthritis
5) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.82 Pain Relevance 0.42
In the present study, we have demonstrated that FGF8 is selectively expressed in injured joints.
Gene_expression (expressed) of FGF8 in joints
6) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.77 Pain Relevance 0.45
FGF8 was expressed in the fibroblasts after meniscectomy (Figure 1d, arrowheads).
Gene_expression (expressed) of FGF8 in fibroblasts
7) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.45 Pain Relevance 0.16
FGF8 is expressed in synovial cells and concentration-dependently enhances growth of cultured synovial cells.
Gene_expression (expressed) of FGF8 in synovial cells
8) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.63 Pain Relevance 0.25
In the meniscectomized group, FGF8 was expressed on proliferated synovial cells and fibroblasts, but expression of FGF8 was absent or minimal in normal joints.
Neg (absent) Gene_expression (expressed) of FGF8 in joints
9) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.37 Pain Relevance 0.15
Weak expression of FGF8 was also exhibited in the joints in which the ligaments were resected and the articular spaces were exposed (the sham group).
Gene_expression (expression) of FGF8 in joints
10) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.31 Pain Relevance 0.11
These data indicate that expression of FGF8 is induced by chronic joint injury.
Gene_expression (expression) of FGF8 in joint associated with injury
11) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.26 Pain Relevance 0.08
These findings suggest that the expression of FGF8 was induced in synovia and fibroblasts by mechanical injury.
Gene_expression (expression) of FGF8 in fibroblasts associated with injury
12) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.29 Pain Relevance 0.06
The bone weight of the patella was decreased following an injection of FGF8 into the rat joint.
Gene_expression (injection) of FGF8 in joint
13) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.75 Pain Relevance 0.20
The activity of FGF8 on the knee joint was tested by the articular injection of FGF8 to rats.
Gene_expression (injection) of FGF8 in articular
14) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.12 Pain Relevance 0.09
Promotion of growth of rabbit synovial cells by FGF8
Gene_expression (Promotion) of FGF8 in synovial cells
15) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.18 Pain Relevance 0.13
Articular destruction by intraarticular injection of FGF8 into the rat knee joint
Gene_expression (injection) of FGF8 in knee joint
16) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.13 Pain Relevance 0.10
In the absence of FGF8, S-GAG in the ECM was not decreased by the addition of a low concentration of IL-1?
Neg (absence) Gene_expression (absence) of FGF8
17) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.05 Pain Relevance 0
(0.01 ng/ml) and FGF8 (100 ng/ml) for 48 hours, there was a significant decrease in residual S-GAG compared with levels after FGF8 stimulation or IL-1?
Gene_expression (stimulation) of FGF8
18) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
The addition of anti-FGF8 antibody at 0.3 to 10 ?
Gene_expression (antibody) of FGF8
19) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.14 Pain Relevance 0.11
Intraarticular injection of FGF8 in rats
Gene_expression (injection) of FGF8
20) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.10 Pain Relevance 0.05

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