INT250836

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8)
Fgf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 76 80.04 Quite High
Analgesic 4 53.32 Quite High
ketamine 2 50.48 Quite High
Pain 10 48.32 Quite Low
metalloproteinase 16 40.64 Quite Low
Arthritis 30 32.44 Quite Low
Substantia nigra 6 31.76 Quite Low
cytokine 4 26.24 Quite Low
Dopamine 20 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 98.36 Very High Very High Very High
Osteoarthritis 78 80.04 Quite High
Breast Cancer 2 67.36 Quite High
Synovial Sarcoma 2 59.04 Quite High
Cancer 2 57.28 Quite High
INFLAMMATION 17 55.12 Quite High
Pain 10 48.32 Quite Low
Injury 11 43.24 Quite Low
Arthritis 30 32.44 Quite Low
Synovitis 2 16.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FGF8 can bind to three receptors – FGFR2IIIc, FGFR3IIIc, and FGFR4 [15] – and has an important role in embryogenesis and morphogenesis [16].
FGF8 Binding (bind) of
1) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.24 Pain Relevance 0.03
Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding to its receptors.
FGF8b Binding (binding) of
2) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.32 Pain Relevance 0.21
Sonic hedgehog with FGF8b enhanced the differentiaton of Sox1-GFP knock-in ES cells
FGF8b Binding (hedgehog) of associated with targeted disruption
3) Confidence 0.33 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2838763 Disease Relevance 0.10 Pain Relevance 0

General Comments

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