INT250837

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
chondrocytes 2
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 2 97.04 Very High Very High Very High
Osteoarthritis 38 93.72 High High
metalloproteinase 8 88.56 High High
Arthritis 15 81.68 Quite High
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Synovitis 1 94.16 High High
Osteoarthritis 39 93.72 High High
Disease 3 85.40 High High
Genetic Predisposition To Disease 1 82.40 Quite High
Arthritis 15 81.68 Quite High
Injury 5 81.44 Quite High
Stress 2 80.60 Quite High
Aging 1 79.84 Quite High
Cancer 1 31.68 Quite Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of the ECM is caused by the secretion of degradative enzymes from chondrocytes in response to cytokines and prostaglandin E2 (PGE2) within the joint [1,2].
Positive_regulation (caused) of Negative_regulation (Loss) of ECM in chondrocytes associated with cytokine
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.10 Pain Relevance 0.44

General Comments

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