INT250840

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.92
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8)
Fgf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 190 94.48 High High
Inflammation 35 89.24 High High
Pain 25 70.04 Quite High
ketamine 5 57.76 Quite High
metalloproteinase 40 57.24 Quite High
Analgesic 10 51.76 Quite High
Arthritis 75 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 195 94.48 High High
INFLAMMATION 40 89.24 High High
Disease Progression 5 87.76 High High
Pain 25 70.04 Quite High
Synovial Sarcoma 5 40.88 Quite Low
Breast Cancer 5 36.60 Quite Low
Injury 25 15.40 Low Low
Overdose 5 14.32 Low Low
Arthritis 75 5.00 Very Low Very Low Very Low
Hyperplasia 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KM1334 neutralizes the activity of human FGF8, rabbit FGF8, and rat FGF8.


Negative_regulation (neutralizes) of FGF8
1) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.32 Pain Relevance 0.21
KM1334 neutralizes the activity of human FGF8, rabbit FGF8, and rat FGF8.


Negative_regulation (neutralizes) of FGF8
2) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.32 Pain Relevance 0.21
KM1334 neutralizes the activity of human FGF8, rabbit FGF8, and rat FGF8.


Negative_regulation (neutralizes) of FGF8
3) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.32 Pain Relevance 0.21
Anti-FGF8 antibody blocked this FGF8 with IL-1-induced degradation of the ECM.
Negative_regulation (blocked) of FGF8
4) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.84 Pain Relevance 0.38
g/ml significantly inhibited FGF8-induced incorporation of [3H]thymidine.


Negative_regulation (inhibited) of FGF8
5) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.14 Pain Relevance 0.10

General Comments

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