INT250841

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.80
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8)
Anatomy Link Frequency
fibroblasts 5
joint 4
articular 2
synovial cells 1
Fgf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 266 99.04 Very High Very High Very High
Arthritis 105 98.24 Very High Very High Very High
metalloproteinase 56 95.48 Very High Very High Very High
rheumatoid arthritis 14 93.64 High High
Pain 35 90.00 High High
Inflammation 49 71.12 Quite High
fibrosis 7 62.72 Quite High
cytokine 14 49.92 Quite Low
Analgesic 14 39.16 Quite Low
ketamine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 21 100.00 Very High Very High Very High
Injury 35 99.76 Very High Very High Very High
Osteoarthritis 273 99.04 Very High Very High Very High
Arthritis 105 98.24 Very High Very High Very High
Rheumatoid Arthritis 14 93.64 High High
Pain 35 90.00 High High
Disease 21 85.52 High High
INFLAMMATION 56 64.08 Quite High
Fibrosis 7 62.72 Quite High
Syndrome 7 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that expression of FGF8 is induced by chronic joint injury.
Positive_regulation (induced) of Gene_expression (expression) of FGF8 in joint associated with injury
1) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.26 Pain Relevance 0.08
These studies suggest that the injury of synovia induces the expression of FGF8 in the joint, and this may promote degradation of cartilage via a paracrine system.
Positive_regulation (induces) of Gene_expression (expression) of FGF8 in joint associated with injury
2) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.83 Pain Relevance 0.22
These findings suggest that the expression of FGF8 was induced in synovia and fibroblasts by mechanical injury.
Positive_regulation (induced) of Gene_expression (expression) of FGF8 in fibroblasts associated with injury
3) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.29 Pain Relevance 0.06
The activity of FGF8 on the knee joint was tested by the articular injection of FGF8 to rats.
Positive_regulation (injection) of Gene_expression (injection) of FGF8 in articular
4) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.12 Pain Relevance 0.09
The expression of FGF8 in hyperplastic synovial cells and fibroblasts was induced in the meniscectomized OA model, whereas little or no expression was detected in normal synovium.
Positive_regulation (induced) of Gene_expression (expression) of FGF8 in fibroblasts associated with osteoarthritis and hyperplasia
5) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.66 Pain Relevance 0.36
We have demonstrated that the expression of FGF8 on synovia is increased in an experimental model of OA in rabbits.
Positive_regulation (increased) of Gene_expression (expression) of FGF8 associated with osteoarthritis
6) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.98 Pain Relevance 0.54
The expression of FGF8 in hyperplastic synovial cells and fibroblasts was induced in the meniscectomized OA model, whereas little or no expression was detected in normal synovium.
Positive_regulation (induced) of in synovial cells Gene_expression (expression) of FGF8 in fibroblasts associated with osteoarthritis and hyperplasia
7) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.66 Pain Relevance 0.36

General Comments

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