INT250845

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Context Info
Confidence 0.98
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.64
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8)
Anatomy Link Frequency
chondrocytes 1
cartilage 1
fibroblasts 1
Fgf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 60 96.44 Very High Very High Very High
cytokine 8 82.20 Quite High
Osteoarthritis 152 80.12 Quite High
rheumatoid arthritis 8 75.88 Quite High
Pain 20 42.32 Quite Low
Inflammation 28 38.92 Quite Low
fibrosis 4 37.56 Quite Low
Analgesic 8 27.52 Quite Low
metalloproteinase 32 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 12 97.60 Very High Very High Very High
Osteoarthritis 156 96.96 Very High Very High Very High
Arthritis 60 96.44 Very High Very High Very High
Injury 20 87.88 High High
Syndrome 4 82.72 Quite High
Stress 8 81.76 Quite High
Rheumatoid Arthritis 8 75.88 Quite High
Disease 12 73.88 Quite High
Pain 20 42.32 Quite Low
INFLAMMATION 32 38.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Degradation of the extracellular matrix of chondrocytes by FGF8
Protein_catabolism (Degradation) of FGF8 in chondrocytes
1) Confidence 0.98 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.08 Pain Relevance 0
These data indicate that systemic application of anti-FGF8 antibody protects the FGF8-dependent cartilage degradation.
Protein_catabolism (degradation) of FGF8-dependent in cartilage
2) Confidence 0.98 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.77 Pain Relevance 0.29
Bone degradation following intraarticular injection of FGF8 may therefore be due to the growth of synovial cells and also production of various factors from synoviocytes, fibroblasts, or other cells.
Protein_catabolism (degradation) of FGF8 in fibroblasts
3) Confidence 0.98 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.72 Pain Relevance 0.19
FGF8 dose-dependently induced ECM degradation.
Protein_catabolism (degradation) of FGF8
4) Confidence 0.87 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.07 Pain Relevance 0

General Comments

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