INT250847

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.72
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
chondrocytes 1
knee joints 1
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 96.64 Very High Very High Very High
Arthritis 30 95.28 Very High Very High Very High
Osteoarthritis 76 94.28 High High
metalloproteinase 16 87.76 High High
Inflammation 14 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 30 95.28 Very High Very High Very High
Osteoarthritis 78 94.28 High High
Synovitis 2 94.16 High High
Hyperplasia 6 91.52 High High
Disease 6 85.40 High High
Genetic Predisposition To Disease 2 82.40 Quite High
Injury 10 81.44 Quite High
Stress 4 80.60 Quite High
Aging 2 79.84 Quite High
Cancer 2 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of FGF8 into rat knee joints induced the degradation of the ECM, which was suppressed by anti-FGF8 antibody.
Negative_regulation (suppressed) of ECM in knee joints
1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.61 Pain Relevance 0.35
Loss of the ECM is caused by the secretion of degradative enzymes from chondrocytes in response to cytokines and prostaglandin E2 (PGE2) within the joint [1,2].
Negative_regulation (Loss) of ECM in chondrocytes associated with cytokine
2) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.10 Pain Relevance 0.43

General Comments

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