INT250850

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.79
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8)
Anatomy Link Frequency
joints 4
knee joints 2
patella 2
Fgf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 152 97.96 Very High Very High Very High
Analgesic 8 91.04 High High
Pain 20 82.68 Quite High
rheumatoid arthritis 8 81.52 Quite High
Inflammation 28 79.32 Quite High
Arthritis 60 72.28 Quite High
cytokine 8 62.72 Quite High
metalloproteinase 32 9.04 Low Low
ketamine 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 156 97.96 Very High Very High Very High
Hyperplasia 12 97.60 Very High Very High Very High
Injury 20 93.52 High High
INFLAMMATION 32 85.48 High High
Pain 20 82.68 Quite High
Rheumatoid Arthritis 8 81.52 Quite High
Disease 12 79.52 Quite High
Arthritis 60 77.92 Quite High
Synovial Sarcoma 4 72.80 Quite High
Syndrome 4 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following injection of FGF8, the weight of the patella was reduced.
Negative_regulation (reduced) of Gene_expression (injection) of FGF8 in patella
1) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.86 Pain Relevance 0.57
Initially, a rabbit meniscectomy model of OA, in which typical degenerative changes are observed in the operated knee joints [22,23], was used to detect the expression of FGF8.
Negative_regulation (detect) of Gene_expression (expression) of FGF8 in knee joints associated with osteoarthritis
2) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.82 Pain Relevance 0.42
Weak expression of FGF8 was also exhibited in the joints in which the ligaments were resected and the articular spaces were exposed (the sham group).
Negative_regulation (exhibited) of Gene_expression (expression) of FGF8 in joints
3) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.31 Pain Relevance 0.11
The bone weight of the patella was decreased following an injection of FGF8 into the rat joint.
Negative_regulation (decreased) of Gene_expression (injection) of FGF8 in joint
4) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.80 Pain Relevance 0.23

General Comments

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