INT250856

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8, Mmp3) peptidase activity (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
chondrocytes 2
Fgf8 (Rattus norvegicus)
Mmp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 100.00 Very High Very High Very High
Arthritis 15 96.04 Very High Very High Very High
Osteoarthritis 38 86.60 High High
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 15 96.04 Very High Very High Very High
Osteoarthritis 39 86.60 High High
Hyperplasia 3 83.84 Quite High
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured chondrocytes, FGF8 induced the release of matrix metalloproteinase 3 and prostaglandin E2, and caused degradation of the ECM.
FGF8 Positive_regulation (induced) of Localization (release) of matrix metalloproteinase 3 in chondrocytes associated with metalloproteinase
1) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.51 Pain Relevance 0.30

General Comments

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