INT250861

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.51
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
chondrocytes 4
Fgf8 (Rattus norvegicus)
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 15 99.92 Very High Very High Very High
Inflammation 21 99.56 Very High Very High Very High
Osteoarthritis 114 93.12 High High
metalloproteinase 24 47.72 Quite Low
Analgesic 6 44.08 Quite Low
Arthritis 45 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 15 99.92 Very High Very High Very High
INFLAMMATION 24 99.56 Very High Very High Very High
Osteoarthritis 117 93.12 High High
Disease Progression 3 78.24 Quite High
Injury 15 10.20 Low Low
Arthritis 45 5.00 Very Low Very Low Very Low
Hyperplasia 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of PGE2, which was induced by FGF8, decreased dose-dependently in the presence of anti-FGF8 antibody at 1 to 10 ?
FGF8 Positive_regulation (induced) of Gene_expression (production) of PGE2
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.19 Pain Relevance 0.14
FGF8 induced the production of PGE2 from cultured chondrocytes.
FGF8 Positive_regulation (induced) of Gene_expression (production) of PGE2 in chondrocytes
2) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.12 Pain Relevance 0.55
FGF8 significantly increased the production of PGE2 from the chondrocytes (P = 0.0063; Figure 3b).
FGF8 Positive_regulation (increased) of Gene_expression (production) of PGE2 in chondrocytes
3) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.20 Pain Relevance 0.15

General Comments

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