INT250867

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 4.35
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8, Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
chondrocytes 6
Fgf8 (Rattus norvegicus)
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 88 100.00 Very High Very High Very High
Osteoarthritis 418 99.48 Very High Very High Very High
Inflammation 77 97.44 Very High Very High Very High
Arthritis 165 96.04 Very High Very High Very High
rheumatoid arthritis 22 92.16 High High
Pain 55 86.56 High High
Analgesic 22 43.80 Quite Low
cytokine 22 41.44 Quite Low
fibrosis 11 29.16 Quite Low
ketamine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 55 99.92 Very High Very High Very High
Osteoarthritis 429 99.48 Very High Very High Very High
INFLAMMATION 88 97.44 Very High Very High Very High
Arthritis 165 96.04 Very High Very High Very High
Rheumatoid Arthritis 22 92.16 High High
Disease Progression 11 92.00 High High
Disease 33 90.16 High High
Pain 55 86.56 High High
Hyperplasia 33 83.84 Quite High
Syndrome 11 49.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicated that FGF8 may promote degradation of the ECM by production of proteases including MMP-3.
FGF8 Spec (may) Positive_regulation (promote) of Protein_catabolism (degradation) of ECM
1) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.17 Pain Relevance 0.13
FGF8 and IL-1 synergistically accelerated the degradation of the ECM.
FGF8 Positive_regulation (accelerated) of Protein_catabolism (degradation) of ECM
2) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.58 Pain Relevance 0.29
FGF8 also induced degradation of the ECM in cultured chondrocytes.
FGF8 Positive_regulation (induced) of Protein_catabolism (degradation) of ECM in chondrocytes
3) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.67 Pain Relevance 0.21
In cultured chondrocytes, degradation of the ECM induced by FGF8 was further enhanced by a small amount of IL-1.
FGF8 Positive_regulation (induced) of Protein_catabolism (degradation) of ECM in chondrocytes
4) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.79 Pain Relevance 0.38
FGF8 dose-dependently induced ECM degradation.
FGF8 Positive_regulation (induced) of Protein_catabolism (degradation) of ECM
5) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.07 Pain Relevance 0
In cultured chondrocytes, FGF8 induced the release of matrix metalloproteinase 3 and prostaglandin E2, and caused degradation of the ECM.
FGF8 Positive_regulation (caused) of Protein_catabolism (degradation) of ECM in chondrocytes associated with metalloproteinase
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.51 Pain Relevance 0.30
Degradation of the ECM was promoted in the presence of FGF8.
FGF8 Positive_regulation (promoted) of Protein_catabolism (Degradation) of ECM
7) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.25 Pain Relevance 0.08
FGF8 at 10 ng/ml did not induce ECM degradation.
FGF8 Neg (not) Positive_regulation (induce) of Protein_catabolism (degradation) of ECM
8) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
FGF8 induced production of MMP-3 and PGE2, and caused degradation of the ECM in vitro.
FGF8 Positive_regulation (caused) of Protein_catabolism (degradation) of ECM
9) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.02 Pain Relevance 0.58
A concentration of FGF8 (100 ng/ml) that caused ECM degradation was used.
FGF8 Positive_regulation (caused) of Protein_catabolism (degradation) of ECM
10) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
Degradation of the ECM is enhanced by FGF8.
FGF8 Positive_regulation (enhanced) of Protein_catabolism (Degradation) of ECM
11) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.27 Pain Relevance 0.18

General Comments

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