INT250868

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.73
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8, Mmp3) peptidase activity (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
chondrocytes 6
Fgf8 (Rattus norvegicus)
Mmp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 152 99.48 Very High Very High Very High
Arthritis 60 94.80 High High
metalloproteinase 32 93.52 High High
rheumatoid arthritis 8 90.20 High High
Pain 20 86.56 High High
Inflammation 28 72.96 Quite High
cytokine 8 38.32 Quite Low
Analgesic 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 156 99.48 Very High Very High Very High
Arthritis 60 94.80 High High
Rheumatoid Arthritis 8 90.20 High High
Pain 20 86.56 High High
INFLAMMATION 32 72.96 Quite High
Injury 20 71.44 Quite High
Disease Progression 4 56.56 Quite High
Stress 8 37.88 Quite Low
Syndrome 4 34.52 Quite Low
Hyperplasia 12 20.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, FGF8 induced the production of proMMP-3 and significantly decreased the residual amount of S-GAG in the ECM in cultured chondrocytes.
FGF8 Positive_regulation (induced) of Gene_expression (production) of proMMP-3 in chondrocytes
1) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.46 Pain Relevance 0.22
FGF8 induced the production of proMMP-3 by cultured chondrocytes, and anti-FGF8 antibody attenuated the release of these factors.
FGF8 Positive_regulation (induced) of Gene_expression (production) of proMMP-3 in chondrocytes
2) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.19 Pain Relevance 0.10
Stimulation of proMMP-3 and prostaglandin E2 production by FGF8 in rabbit chondrocytes
FGF8 Positive_regulation (Stimulation) of Gene_expression (production) of proMMP-3 in chondrocytes
3) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.12 Pain Relevance 0.09
FGF8 induced production of MMP-3 and PGE2, and caused degradation of the ECM in vitro.
FGF8 Positive_regulation (induced) of Gene_expression (production) of MMP-3
4) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.97 Pain Relevance 0.53

General Comments

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