INT250871

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.44
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1a, Ecm1) extracellular region (Il1a, Ecm1) enzyme binding (Ecm1)
signal transducer activity (Ecm1) cytosol (Il1a) signal transduction (Ecm1)
Anatomy Link Frequency
chondrocytes 2
Il1a (Rattus norvegicus)
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 76 98.72 Very High Very High Very High
Inflammation 14 97.44 Very High Very High Very High
metalloproteinase 16 82.08 Quite High
Pain 10 44.96 Quite Low
Analgesic 4 20.56 Low Low
Arthritis 30 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 78 98.72 Very High Very High Very High
INFLAMMATION 16 97.44 Very High Very High Very High
Disease Progression 2 92.00 High High
Pain 10 44.96 Quite Low
Injury 10 40.24 Quite Low
Arthritis 30 9.24 Low Low
Hyperplasia 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FGF8 and IL-1 synergistically accelerated the degradation of the ECM.
IL-1 Positive_regulation (accelerated) of Protein_catabolism (degradation) of ECM
1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.58 Pain Relevance 0.29
In cultured chondrocytes, degradation of the ECM induced by FGF8 was further enhanced by a small amount of IL-1.
IL-1 Positive_regulation (enhanced) of Protein_catabolism (degradation) of ECM in chondrocytes
2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.86 Pain Relevance 0.39

General Comments

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