INT250878

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1a, Fgf8, Ecm1) extracellular region (Il1a, Ecm1) enzyme binding (Ecm1)
signal transducer activity (Ecm1) cytosol (Il1a) signal transduction (Ecm1)
Anatomy Link Frequency
chondrocytes 2
Il1a (Rattus norvegicus)
Fgf8 (Rattus norvegicus)
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 38 97.96 Very High Very High Very High
Inflammation 7 92.72 High High
metalloproteinase 8 60.72 Quite High
Pain 5 44.96 Quite Low
Analgesic 2 20.56 Low Low
Arthritis 15 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 39 97.96 Very High Very High Very High
INFLAMMATION 8 92.72 High High
Disease Progression 1 91.24 High High
Pain 5 44.96 Quite Low
Injury 5 18.88 Low Low
Arthritis 15 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured chondrocytes, degradation of the ECM induced by FGF8 was further enhanced by a small amount of IL-1.
IL-1 Positive_regulation (enhanced) of FGF8 Positive_regulation (induced) of ECM in chondrocytes
1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.85 Pain Relevance 0.38

General Comments

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