INT250884

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 7.17
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A)
Anatomy Link Frequency
T-cell 2
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 166 98.96 Very High Very High Very High
rheumatoid arthritis 259 98.28 Very High Very High Very High
cytokine 122 85.92 High High
methotrexate 34 85.24 High High
corticosteroid 9 82.40 Quite High
chemokine 12 82.04 Quite High
cINOD 3 81.32 Quite High
Inflammation 150 80.64 Quite High
Etanercept 53 79.64 Quite High
Arthritis 49 78.88 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 205 98.96 Very High Very High Very High
Inflammatory Bowel Disease 39 98.52 Very High Very High Very High
Rheumatoid Arthritis 260 98.28 Very High Very High Very High
Disease 133 98.00 Very High Very High Very High
Malaria 163 87.80 High High
Colitis 8 86.28 High High
Infection 146 81.80 Quite High
INFLAMMATION 157 80.64 Quite High
Seronegative Spondarthritis 39 78.88 Quite High
Osteoarthritis 30 78.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
p19 Binding (alteration) of associated with psoriasis
1) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.01 Pain Relevance 0.51
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
IL-23 Binding (alteration) of associated with psoriasis
2) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.01 Pain Relevance 0.51
Both IL-12 and IL-23 have been associated with the pathogenesis of psoriasis, in part due to their relationship to the differentiation of naïve T-cells into Th1 and Th17 cells5,6 (Figure 1).
IL-23 Binding (associated) of in T-cells associated with psoriasis
3) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.23 Pain Relevance 0.69
Like IL-23, IL-27 and IFN-?
IL-23 Binding (Like) of
4) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.02 Pain Relevance 0.51
Following treatment with IL-23 plus P/I, the abundance of TH-17 cells in RA SF was significantly (p < 0.05) greater than observed with normal PB and RA PB treated in the same fashion (Figures 1b, 1f and 2).
IL-23 Binding (treatment) of associated with rheumatoid arthritis
5) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.34 Pain Relevance 0.67
Yet, embracing the complexity that constitutes the human immune milieu, the recognition of IL-12 and IL-23 in orchestrating the development of TH1 and TH17 subsets, respectively, pose new questions in T-cell decision making [reviewed in (84)].
IL-23 Binding (recognition) of in T-cell
6) Confidence 0.13 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.37 Pain Relevance 0.08
Similar associations in IL-23 pathway genes have been observed in UC.
IL-23 Binding (associations) of associated with inflammatory bowel disease
7) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 1.19 Pain Relevance 0.20

General Comments

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