INT250886

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.91
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IL23R)
Anatomy Link Frequency
T-cells 2
memory T cells 2
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 131 99.64 Very High Very High Very High
cytokine 78 84.16 Quite High
Inflammation 65 76.80 Quite High
psoriasis 2 72.08 Quite High
Crohn's disease 8 71.20 Quite High
Multiple sclerosis 2 69.52 Quite High
tolerance 26 5.00 Very Low Very Low Very Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
methotrexate 8 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 133 99.64 Very High Very High Very High
Disease 50 78.80 Quite High
INFLAMMATION 62 76.80 Quite High
Psoriasis 2 72.08 Quite High
Demyelinating Disease 2 69.52 Quite High
Communicable Diseases 4 50.32 Quite High
Cancer 68 43.88 Quite Low
Autoimmune Disease 24 29.48 Quite Low
Inflammatory Bowel Disease 60 5.00 Very Low Very Low Very Low
Colitis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The origin of TH17 cells is controversial: in human, TH17 cells originate from CD161+ naive CD4+ T-cells precursor, which constitutively express RORgammat and IL-23R, in response to the combined activity of IL-1beta and IL-23.
Positive_regulation (response) of Gene_expression (express) of IL-23R in T-cells
1) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.67 Pain Relevance 0.37
High concentration of TGF-beta represses IL-23R expression and favors FoxP3+ Treg cells [69].
Positive_regulation (represses) of Gene_expression (expression) of IL-23R
2) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0 Pain Relevance 0.07
The expression of IL-23R is increased on CD45RO memory T cells, and IL-23 may also induce the expression of its own receptor [21,22].
Positive_regulation (increased) of Gene_expression (expression) of IL-23R in memory T cells
3) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.24 Pain Relevance 0.63

General Comments

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