INT25089

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Context Info
Confidence 0.00
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Glul, Npr1) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) protein complex (Glul) ligase activity (Glul)
Anatomy Link Frequency
neuronal 1
brain 1
Glul (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 2 98.92 Very High Very High Very High
Potency 2 93.60 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results correlate the loss of Gs-stimulated adenylate cyclase with a loss of transfer of nucleotide from Gi/o to Gs alpha-subunits and suggest that the nucleotide exchange participates in the modulation of neuronal adenylate cyclase.
Gs-stimulated Positive_regulation (stimulated) of cyclase in neuronal
1) Confidence 0.00 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2498464 Disease Relevance 0 Pain Relevance 0.10
Pretreatment of rat brain membranes at pH 4.5 before assay at pH 7.4 modifies the function of GTP-binding proteins (G-proteins) by eliminating Gs-stimulated adenylate cyclase activity while increasing opiate-inhibited adenylate cyclase activity.
Gs-stimulated Positive_regulation (stimulated) of cyclase in brain associated with opiate
2) Confidence 0.00 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2498464 Disease Relevance 0 Pain Relevance 0.10

General Comments

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