INT250890

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.11
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IL23R)
Anatomy Link Frequency
T-cells 1
memory T cells 1
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 134 99.64 Very High Very High Very High
cytokine 186 91.48 High High
chemokine 16 79.56 Quite High
Inflammation 161 75.76 Quite High
psoriasis 5 71.04 Quite High
Crohn's disease 20 70.16 Quite High
Multiple sclerosis 5 68.48 Quite High
Infliximab 5 27.32 Quite Low
Inflammatory response 5 11.48 Low Low
tolerance 65 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 150 99.92 Very High Very High Very High
Rheumatoid Arthritis 139 99.64 Very High Very High Very High
Disease 116 93.80 High High
Colitis 40 83.80 Quite High
INFLAMMATION 152 75.76 Quite High
Psoriasis 5 71.04 Quite High
Demyelinating Disease 5 68.48 Quite High
Communicable Diseases 10 49.28 Quite Low
Cancer 167 47.32 Quite Low
Autoimmune Disease 60 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At low concentration, TGF-beta synergizes with IL-6 and IL-21 to promote IL-23R expression, favoring TH17 cell differentiation.
Gene_expression (expression) of IL-23R
1) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0 Pain Relevance 0.06
Moreover, TH17 cells are also characterized by the surface expression of CCR6, IL-23R, IL-12Rbeta2, and CD161.
Gene_expression (expression) of IL-23R
2) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.16 Pain Relevance 0.21
High concentration of TGF-beta represses IL-23R expression and favors FoxP3+ Treg cells [69].
Gene_expression (expression) of IL-23R
3) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0 Pain Relevance 0.07
The origin of TH17 cells is controversial: in human, TH17 cells originate from CD161+ naive CD4+ T-cells precursor, which constitutively express RORgammat and IL-23R, in response to the combined activity of IL-1beta and IL-23.
Gene_expression (express) of IL-23R in T-cells
4) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.61 Pain Relevance 0.37
IL-23R is a key differentiation feature of CD4-TH17 effector cells that are critical in mediating antimicrobial defenses, is highly expressed by TH17 cells, and has a role in their maintenance.
Gene_expression (expressed) of IL-23R
5) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 1.10 Pain Relevance 0.21
The expression of IL-23R is increased on CD45RO memory T cells, and IL-23 may also induce the expression of its own receptor [21,22].
Gene_expression (expression) of IL-23R in memory T cells
6) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.24 Pain Relevance 0.62

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox