INT250897

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tgm2) mitochondrion (Tgm2) proteinaceous extracellular matrix (Tgm2)
plasma membrane (Tgm2) transferase activity, transferring acyl groups (Tgm2) cytoplasm (Tgm2)
Anatomy Link Frequency
skin 1
Tgm2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 81.88 Quite High
cytokine 1 76.04 Quite High
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 94.08 High High
Injury 1 85.72 High High
Obesity 1 74.24 Quite High
Intervertebral Disk Degeneration 4 9.44 Low Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Intervertebral Disk Displacement 3 5.00 Very Low Very Low Very Low
Calcification 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent work has also shown that the TSP-2-null mouse has a reduction in tissue transglutaminase, an enzyme that acts to introduce covalent intermolecular cross-links in collagen and other proteins; this finding accounts in part for the matrix abnormalities seen in the TSP-2-null mouse, such as fragile skin and lax ligaments [2].
Negative_regulation (reduction) of tissue transglutaminase in skin associated with congenital anomalies
1) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.25 Pain Relevance 0.12

General Comments

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