INT250899

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 4.97
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Thbs2) cell adhesion (Thbs2) structural molecule activity (Thbs2)
Anatomy Link Frequency
annulus 8
follicle 1
vessels 1
extracellular matrix 1
body 1
Thbs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 16 94.56 High High
metalloproteinase 60 82.72 Quite High
Pain 16 21.60 Low Low
alcohol 15 16.16 Low Low
palliative 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 67 100.00 Very High Very High Very High
Endometrial Cancer 201 98.22 Very High Very High Very High
Cancer 197 83.40 Quite High
Calcification 15 80.32 Quite High
Apoptosis 14 78.84 Quite High
Intervertebral Disk Degeneration 60 78.80 Quite High
Injury 15 69.52 Quite High
Carcinoma In Situ 15 65.68 Quite High
Adhesions 50 59.36 Quite High
Disease 24 59.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies confirm the expression of TSP-2 in both the human annulus and the WT mouse annulus, but show no vascular ingrowth into the discs of TSP-2-null mice.


Gene_expression (expression) of TSP-2 in annulus
1) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.29 Pain Relevance 0
Our studies show that, even in the absence of expression of the TSP-2 gene, vascular ingrowth into the body of the disc did not occur.
Gene_expression (expression) of TSP-2 gene in body
2) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.23 Pain Relevance 0
The GCOS Affymetrix GeneChip Operating System (version 1.2) was used to determine gene expression levels for TSP-2 (NM_003247.1).


Gene_expression (expression) of TSP-2
3) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
TSP-2 was present in some cells in the outer annulus of the disc in WT mice (Figure 3a) and in some cells in the region between the central part of the nucleus pulposus and the adjacent vertebral endplate (similar to the localization pattern shown in Figure 2b for TSP-1) (data not shown).
Gene_expression (present) of TSP-2 in annulus
4) Confidence 0.66 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
One objective of this work was to examine mice with a targeted disruption of the TSP-2 gene to determine whether mice lacking TSP-2 would show enhanced vascularity of the adult annulus.
Gene_expression (disruption) of TSP-2 gene in annulus associated with targeted disruption
5) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.25 Pain Relevance 0
The objective of the present work was to examine mice with a targeted disruption of the TSP-2 gene to determine whether mice lacking TSP-2 would show enhanced vascularity of the adult annulus.
Gene_expression (disruption) of TSP-2 gene in annulus associated with targeted disruption
6) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.26 Pain Relevance 0
We examined both the location and expression of TSP-2 in the human disc, and its location in the disc and bordering soft tissues of 5-month-old normal wild-type (WT) mice and of mice with a targeted disruption of the TSP-2 gene.
Gene_expression (expression) of TSP-2 associated with targeted disruption
7) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575610 Disease Relevance 0.09 Pain Relevance 0
Microarray analysis also verified expression of TSP-2 in the human annulus.
Gene_expression (expression) of TSP-2 in annulus
8) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
TSP-2 was found to be present in some, but not all, annulus cells of the human annulus and the mouse annulus.
Gene_expression (present) of TSP-2 in annulus
9) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575610 Disease Relevance 0.16 Pain Relevance 0
It is interesting that the response to a lack of TSP-2 expression in null mice was insufficient to produce vascular ingrowth into the disc.
Gene_expression (expression) of TSP-2
10) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
The thrombospondins (TSPs) are multifunctional matricellular proteins; TSP-1 and TSP-2 have strong anti-angiogenic properties, are present in a number of tissues where they bind to the extracellular matrix (ECM) and, in turn, are themselves able to bind receptors, enzymes, cytokines, proteases, and other ECM proteins [1-6].
Gene_expression (present) of TSP-2 in extracellular matrix associated with cytokine
11) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.07 Pain Relevance 0.13
Affymetrix gene array expression analysis also provided independent confirmation of the expression of TSP-2 in the annulus of four human specimens (Thompson grades III and IV).
Gene_expression (expression) of TSP-2 in annulus
12) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
TSP-2 and its gene expression in human discs
Gene_expression (expression) of TSP-2
13) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
TSP-2, a matricellular protein with recognized anti-angiogenic activity in vivo and in vitro, was found to be present in some, but not all, cells of the human and mouse annulus.
Gene_expression (present) of TSP-2 in annulus
14) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
The annulus contains TSP-2, but apparently does not rely solely upon it to inhibit blood vessel growth; TSP-2 may therefore not participate in regression of neonatal vessels in the disc.


Gene_expression (contains) of TSP-2 in vessels
15) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0 Pain Relevance 0
Thbs2 is also found in Table 3, and encodes thrombospondin 2, an antiangiogenic protein involved in follicle development [26].
Gene_expression (found) of Thbs2 in follicle
16) Confidence 0.55 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Other genes inactivated by promoter hypermethylation in endometrial cancer include PgR [69], the cell cycle control genes 14-3-3 sigma [70], homeobox gene HOXA11, thrombospondin-2 gene (THBS2) [71], paternally expressed gene 3 (PEG3) [72], as well as the detoxifying enzyme glutathione S-transferase P1 (GSTP1) [73].
Gene_expression (expressed) of THBS2 associated with endometrial cancer
17) Confidence 0.33 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.20 Pain Relevance 0
Other genes inactivated by promoter hypermethylation in endometrial cancer include PgR [69], the cell cycle control genes 14-3-3 sigma [70], homeobox gene HOXA11, thrombospondin-2 gene (THBS2) [71], paternally expressed gene 3 (PEG3) [72], as well as the detoxifying enzyme glutathione S-transferase P1 (GSTP1) [73].
Gene_expression (expressed) of thrombospondin-2 gene associated with endometrial cancer
18) Confidence 0.33 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.21 Pain Relevance 0
Other genes inactivated by promoter hypermethylation in endometrial cancer include PgR [69], the cell cycle control genes 14-3-3 sigma [70], homeobox gene HOXA11, thrombospondin-2 gene (THBS2) [71], paternally expressed gene 3 (PEG3) [72], as well as the detoxifying enzyme glutathione S-transferase P1 (GSTP1) [73].
Gene_expression (expressed) of thrombospondin-2 gene associated with endometrial cancer
19) Confidence 0.29 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.21 Pain Relevance 0

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