INT250921

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.55
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CREG1) oxidoreductase activity (CREG1) extracellular region (CREG1)
transcription factor binding (CREG1)
CREG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 384 98.56 Very High Very High Very High
Inflammation 96 90.96 High High
cytokine 56 72.76 Quite High
metalloproteinase 8 66.76 Quite High
fibrosis 12 61.04 Quite High
Osteoarthritis 192 52.16 Quite High
chemokine 8 24.80 Low Low
methotrexate 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 56 100.00 Very High Very High Very High
Down Syndrome 12 98.92 Very High Very High Very High
Rheumatoid Arthritis 384 98.56 Very High Very High Very High
Disease 56 97.24 Very High Very High Very High
INFLAMMATION 96 90.96 High High
Glioma 8 69.36 Quite High
Hyperplasia 4 64.80 Quite High
Necrosis 8 61.76 Quite High
Asthma 4 61.60 Quite High
Cancer 8 61.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In trisomy 21, for instance, inter-individual expression variances affect a number of tightly regulated genes.
Regulation (affect) of genes associated with down syndrome
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.92 Pain Relevance 0.18
Pro-apoptotic genes are not affected in this pathway, corresponding to the absence of gene expression variances within the complex of p53-induced apoptosis (data not shown).
Neg (not) Regulation (affected) of genes associated with apoptosis
2) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.48 Pain Relevance 0.47
In trisomy 21, for instance, inter-individual expression variances affect a number of tightly regulated genes.
Regulation (affect) of genes associated with down syndrome
3) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.92 Pain Relevance 0.18
Regarding apoptosis, genes particularly involved in the regulation of cell survival and anti-apoptosis are significantly affected by expression variances (Figure 5) [70].
Regulation (affected) of genes associated with apoptosis
4) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.23 Pain Relevance 0.39

General Comments

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