INT250927

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.39
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CREG1) oxidoreductase activity (CREG1) extracellular region (CREG1)
transcription factor binding (CREG1)
Anatomy Link Frequency
joint 2
CREG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 100.00 Very High Very High Very High
rheumatoid arthritis 192 99.56 Very High Very High Very High
Osteoarthritis 96 68.48 Quite High
cytokine 28 65.56 Quite High
fibrosis 6 55.36 Quite High
chemokine 4 17.60 Low Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 100.00 Very High Very High Very High
Arthropathy 4 99.64 Very High Very High Very High
Rheumatoid Arthritis 192 99.56 Very High Very High Very High
Apoptosis 28 96.88 Very High Very High Very High
Disease 28 90.96 High High
Frailty 98 68.48 Quite High
Hyperplasia 2 59.12 Quite High
Fibrosis 6 55.36 Quite High
Down Syndrome 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the respective genes in this particular pathway also show increased expression levels in RA SM (data not shown).
Positive_regulation (increased) of Gene_expression (expression) of genes associated with rheumatoid arthritis
1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.33 Pain Relevance 0.40
Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease characterized by overexpression of pro-inflammatory/pro-destructive genes and other activating genes (for example, proto-oncogenes) in the synovial membrane (SM).
Positive_regulation (overexpression) of Gene_expression (overexpression) of genes in joint associated with inflammation, rheumatoid arthritis and arthropathy
2) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575612 Disease Relevance 1.06 Pain Relevance 0.40

General Comments

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