INT250961

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.75
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (SETDB1) Golgi apparatus (SETDB1) nucleolus (SETDB1)
chromosome (SETDB1) plasma membrane (SETDB1) nucleus (SETDB1)
Anatomy Link Frequency
KG-1 6
dendritic cells 1
SETDB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 98 81.68 Quite High
Arthritis 35 52.16 Quite High
Inflammation 21 51.76 Quite High
imagery 7 11.00 Low Low
Disease Link Frequency Relevance Heat
Low Back Pain 98 81.68 Quite High
Disease 49 73.00 Quite High
Cytomegalovirus Infection 7 69.04 Quite High
Arthritis 28 52.16 Quite High
Targeted Disruption 35 49.08 Quite Low
Stress 7 35.16 Quite Low
Seronegative Spondarthritis 7 5.00 Very Low Very Low Very Low
Viral Infection 7 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KG-1, which do not express endogenous HLA-B27, were transfected with non-tagged and epitope-tagged versions of HLA-B*2705 cDNA.
Gene_expression (transfected) of KG-1 in KG-1
1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.06 Pain Relevance 0
KG-1, which do not express endogenous HLA-B27, were transfected with non-tagged and epitope-tagged versions of HLA-B*2705 cDNA.
Neg (not) Gene_expression (express) of KG-1 in KG-1
2) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.06 Pain Relevance 0
Cells expressing epitope-tagged HLA-B27 (KG-1.B27sv5) up-regulated cell surface expression (Figures 1c, d), as did transfectants expressing non-epitope tagged HLA-B27 (not shown).
Gene_expression (expressing) of KG-1 in KG-1
3) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.07 Pain Relevance 0
The human KG-1 cell line (expressing HLA-A30, -A31, -B35 and -Cw4; ECACC, HPA Cultures, Wiltshire, UK) was maintained in Iscove's Modified Dulbecco's Medium (IMDM) (Gibco, Paisley, UK), plus 20% fetal bovine serum ([FBS] Gibco, Paisley, UK) and kanamycin (Gibco, Paisley, UK).
Gene_expression (expressing) of KG-1 in KG-1
4) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.21 Pain Relevance 0.14
Significantly, the formation of HLA-B27 homodimers in transfected KG-1 cells is induced by maturation, with a transient induction also seen in LPS-stimulated human monocyte-derived dendritic cells expressing HLA-B27.
Gene_expression (transfected) of KG-1 in dendritic cells
5) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575614 Disease Relevance 0.21 Pain Relevance 0.21
Stable transfectants of KG-1 made with cDNA for HLA-B*2705 with and without the C-terminal sv5 epitope tag [16] were generated using the Amaxa Nucleofector (Amaxa AG., Cologne, Germany).
Neg (without) Gene_expression (made) of KG-1 in KG-1
6) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.13 Pain Relevance 0.07
A spot resolved at 80 kDa directly above the HLA-B27 monomer in transfected KG-1 cells (Figure 3c), which was the result expected for two associated heavy chains possessing an identical isoelectric point of the HLA-B27 monomer.
Gene_expression (transfected) of KG-1 in KG-1
7) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0 Pain Relevance 0

General Comments

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