INT250978

Context Info Confidence 0.16 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 8 Disease Relevance 12.32 Pain Relevance 8.75

extracellular space (FMOD) extracellular region (FMOD) proteinaceous extracellular matrix (FMOD) intracellular (FMOD)

Anatomy Link Frequency central nervous system 1 FMOD (Homo sapiens)

Pain Link Frequency Relevance Heat Fibrositis 1002 100.00 Neuropathic pain 10 100.00 Pain 402 99.98 diffuse noxious inhibitory control 33 99.92 depression 105 99.66 Central nervous system 31 99.34 Pain score 80 98.68 Duloxetine 420 98.36 Pain threshold 27 98.08 pregabalin 315 97.68

Disease Link Frequency Relevance Heat Fibromyalgia 1002 100.00 Neuropathic Pain 21 100.00 Temporomandibular Joint Disorders 18 100.00 Pain 546 99.98 Depression 185 99.88 Syndrome 18 99.48 Anxiety Disorder 75 99.34 Sleep Disorders 24 98.40 Hypertension 10 92.00 Chronic Disease 5 90.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Other candidate genes evaluated but not shown to be associated with FM are presented in Table 1.

FM Binding (associated) of associated with fibrositis

1) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.01 Pain Relevance 0.77

Several studies by different groups, using different conditioning stimuli (the acute noxious stimulus) and test stimuli (the stimulus used to measure pain threshold at baseline and following the acute, noxious stimulus), have indicated a deficiency of DNIC in individuals with FM.

FM Binding (individuals) of associated with pain threshold, diffuse noxious inhibitory control and fibrositis

2) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.16 Pain Relevance 1.97

Instead, aberrant pain and sensory processing probably caused by alterations in the central nervous system function are being consistently recognized in FM and related syndromes.

FM Binding (recognized) of in central nervous system associated with pain, syndrome, central nervous system and fibrositis

3) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.39 Pain Relevance 0.50

Recent research suggests that these conditions are in fact differential symptom presentations of a single underlying condition, and that major depressive disorder (MDD) and FM (as well as neuropathic pain) are both associated with neuroplastic changes in the CNS.13 However, in a recent review of the relationship between FM and MDD, Pae et al assert that currently available findings do not support the assumption that MDD and FM refer to the same underlying construct, nor can they be seen as subsidiaries of one disease concept.14

FM Binding (associated) of associated with depression, neuropathic pain, central nervous system, disease and fibrositis

4) Confidence 0.10 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.97 Pain Relevance 0.79

The primary outcome variable for the symptomatic relief of pain associated with FM was comparison of endpoint mean pain scores between each pregabalin group and placebo.

FM Binding (associated) of associated with pregabalin, pain, pain score and fibrositis

5) Confidence 0.10 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.20 Pain Relevance 1.50

This suggests that the pain, anxiety, and depression that frequently occur comorbidly with FM do not share the same underlying mechanism.

FM Binding (occur) of associated with pain, depression, anxiety disorder and fibrositis

6) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 2.55 Pain Relevance 1.57

This finding may have considerable implications for FM treatment if replicated by larger studies, as FM and TMD often occur comorbidly.71

FM Binding (occur) of associated with temporomandibular joint disorders and fibrositis

7) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.60 Pain Relevance 0.92

The rate of duloxetine-related insomnia in FM patients may be of concern (10.4% with duloxetine treatment versus 5.6% with placebo treatment),64 as sleep dysfunction is a major associated symptom with FM.

FM Binding (associated) of associated with sleep disorders, fibrositis and duloxetine

8) Confidence 0.07 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.37 Pain Relevance 0.71

General Comments

This test has worked.