INT250981

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 7.30
Pain Relevance 4.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FMOD) extracellular region (FMOD) proteinaceous extracellular matrix (FMOD)
intracellular (FMOD)
Anatomy Link Frequency
pituitary 1
FMOD (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 677 100.00 Very High Very High Very High
Neuropathic pain 8 99.48 Very High Very High Very High
Pain 267 98.86 Very High Very High Very High
Central nervous system 22 97.16 Very High Very High Very High
tolerance 12 88.88 High High
Spinal cord 4 86.72 High High
Opioid 12 83.68 Quite High
tricyclic antidepressant 28 83.28 Quite High
cINOD 20 83.16 Quite High
sSRI 28 82.80 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 677 100.00 Very High Very High Very High
Depression 141 100.00 Very High Very High Very High
Neuropathic Pain 14 99.48 Very High Very High Very High
Stress 26 98.90 Very High Very High Very High
Pain 371 98.86 Very High Very High Very High
Disease 10 96.60 Very High Very High Very High
Syndrome 6 92.60 High High
Chronic Disease 4 91.16 High High
Fatigue 66 82.88 Quite High
INFLAMMATION 8 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Investigations into the autonomic nervous system and the hypothalamic┬ľpituitary┬ľadrenal axis also suggest a role of these stress-response systems in vulnerability to FM or in symptom expression in FM.
Gene_expression (expression) of FM in pituitary associated with stress and fibrositis
1) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.50 Pain Relevance 0.54
Recent research suggests that these conditions are in fact differential symptom presentations of a single underlying condition, and that major depressive disorder (MDD) and FM (as well as neuropathic pain) are both associated with neuroplastic changes in the CNS.13 However, in a recent review of the relationship between FM and MDD, Pae et al assert that currently available findings do not support the assumption that MDD and FM refer to the same underlying construct, nor can they be seen as subsidiaries of one disease concept.14
Gene_expression (assumption) of FM associated with depression, neuropathic pain, central nervous system, disease and fibrositis
2) Confidence 0.14 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.83 Pain Relevance 0.66
Recent research suggests that these conditions are in fact differential symptom presentations of a single underlying condition, and that major depressive disorder (MDD) and FM (as well as neuropathic pain) are both associated with neuroplastic changes in the CNS.13 However, in a recent review of the relationship between FM and MDD, Pae et al assert that currently available findings do not support the assumption that MDD and FM refer to the same underlying construct, nor can they be seen as subsidiaries of one disease concept.14
Gene_expression (disorder) of FM associated with depression, neuropathic pain, central nervous system, disease and fibrositis
3) Confidence 0.14 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.90 Pain Relevance 0.77
This sensitivity is likely conditioned by the same central sensitivity that is presumed to underlie the heightened response to pain seen in these patients, limiting the use of therapeutic drugs in FM treatment.18
Gene_expression (drugs) of FM associated with pain and fibrositis
4) Confidence 0.14 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.09 Pain Relevance 1.62
Rheumatologists may also diagnose FM in patients who do not satisfy the ACR criteria.
Gene_expression (diagnose) of FM associated with fibrositis
5) Confidence 0.14 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 0.99 Pain Relevance 0.89

General Comments

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