INT250982

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 8.65
Pain Relevance 6.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FMOD) extracellular region (FMOD) proteinaceous extracellular matrix (FMOD)
intracellular (FMOD)
Anatomy Link Frequency
Nerve 1
insula 1
secondary somatosensory cortex 1
FMOD (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 681 100.00 Very High Very High Very High
rheumatoid arthritis 6 99.40 Very High Very High Very High
Nerve growth factor 12 99.36 Very High Very High Very High
central pain 2 97.98 Very High Very High Very High
allodynia 12 96.72 Very High Very High Very High
Neuropeptide 18 96.64 Very High Very High Very High
Hyperalgesia 12 96.32 Very High Very High Very High
Somatosensory cortex 12 95.64 Very High Very High Very High
Calcitonin gene-related peptide 13 95.48 Very High Very High Very High
insula 9 94.76 High High
Disease Link Frequency Relevance Heat
Fibromyalgia 681 100.00 Very High Very High Very High
Rheumatoid Arthritis 6 99.40 Very High Very High Very High
Congenital Anomalies 49 98.48 Very High Very High Very High
Pain 363 97.98 Very High Very High Very High
Nociception 4 97.64 Very High Very High Very High
Neuropathic Pain 15 96.72 Very High Very High Very High
Hyperalgesia 12 96.32 Very High Very High Very High
Stress 41 95.28 Very High Very High Very High
Anxiety Disorder 15 89.20 High High
Autoimmune Disease 6 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antiganglioside antibody and antiphospholipid antibody have each been shown to be increased in FM in two cross-sectional studies by the same group [81,82].
Positive_regulation (increased) of FM associated with fibrositis
1) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.16 Pain Relevance 0.39
Nerve growth factor was shown in one study to have increased levels in FM and not in FM/rheumatoid arthritis overlap, therefore presenting inconclusive results [93].
Positive_regulation (increased) of FM in Nerve associated with nerve growth factor, rheumatoid arthritis and fibrositis
2) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.32 Pain Relevance 1.30
Antithromboplastin antibody [83], antipolymer antibody [84], and anti-68/48 kDa and anti-45 kDa [85] have each been evaluated in one cross-sectional study and have shown increased levels in FM.
Positive_regulation (increased) of FM associated with fibrositis
3) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 0.91 Pain Relevance 0.30
Specifically, several areas of the brain consistently show greater activation in FM patients than in control individuals given the same objective stimulus intensity – especially the secondary somatosensory cortex, insula and the anterior cingulate cortex.
Positive_regulation (activation) of FM in insula associated with somatosensory cortex, insula, anterior cingulate cortex and fibrositis
4) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.16 Pain Relevance 1.49
Antiserotonin antibody has been shown to be increased in FM in three cross-sectional studies by two different groups [81-83].
Positive_regulation (increased) of FM associated with fibrositis
5) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.32 Pain Relevance 0.43
It is now known that systemic nociceptive and central pain processing abnormalities are necessary (although perhaps not sufficient) to condition the onset and maintenance of FM.
Positive_regulation (maintenance) of FM associated with pain, nociception, central pain, congenital anomalies and fibrositis
6) Confidence 0.09 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.62 Pain Relevance 0.68
Specifically, several areas of the brain consistently show greater activation in FM patients than in control individuals given the same objective stimulus intensity – especially the secondary somatosensory cortex, insula and the anterior cingulate cortex.
Positive_regulation (activation) of FM in secondary somatosensory cortex associated with somatosensory cortex, insula, anterior cingulate cortex and fibrositis
7) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.16 Pain Relevance 1.49

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