INT250983

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.62
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FMOD) extracellular region (FMOD) proteinaceous extracellular matrix (FMOD)
intracellular (FMOD)
Anatomy Link Frequency
pituitary 2
FMOD (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 236 100.00 Very High Very High Very High
Pain 96 99.24 Very High Very High Very High
Central nervous system 7 92.76 High High
tolerance 3 89.64 High High
Spinal cord 1 87.48 High High
Opioid 3 84.44 Quite High
cINOD 5 83.92 Quite High
tricyclic antidepressant 7 83.28 Quite High
sSRI 7 82.80 Quite High
Analgesic 6 81.40 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 236 100.00 Very High Very High Very High
Stress 11 100.00 Very High Very High Very High
Pain 128 99.24 Very High Very High Very High
Syndrome 6 95.60 Very High Very High Very High
Disease 7 84.72 Quite High
INFLAMMATION 2 83.36 Quite High
Genetic Predisposition To Disease 2 81.52 Quite High
Cognitive Disorder 17 77.92 Quite High
Fatigue 18 77.32 Quite High
Nervous System Malformation 2 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This sensitivity is likely conditioned by the same central sensitivity that is presumed to underlie the heightened response to pain seen in these patients, limiting the use of therapeutic drugs in FM treatment.18
Regulation (use) of Gene_expression (drugs) of FM associated with pain and fibrositis
1) Confidence 0.09 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.09 Pain Relevance 1.62
Investigations into the autonomic nervous system and the hypothalamic┬ľpituitary┬ľadrenal axis also suggest a role of these stress-response systems in vulnerability to FM or in symptom expression in FM.
Regulation (role) of Gene_expression (expression) of FM in pituitary associated with stress and fibrositis
2) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575617 Disease Relevance 1.53 Pain Relevance 0.55

General Comments

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