INT251

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2011
Negated 59
Speculated 22
Reported most in Body
Documents 398
Total Number 422
Disease Relevance 232.47
Pain Relevance 55.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 49
blood 30
body 12
adipocytes 8
fat 7
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 891 100.00 Very High Very High Very High
cytokine 582 100.00 Very High Very High Very High
Angina 137 100.00 Very High Very High Very High
depression 126 100.00 Very High Very High Very High
narcan 103 100.00 Very High Very High Very High
Clonidine 71 100.00 Very High Very High Very High
opiate 69 100.00 Very High Very High Very High
Catecholamine 56 100.00 Very High Very High Very High
Serotonin 50 100.00 Very High Very High Very High
addiction 34 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 10377 100.00 Very High Very High Very High
Insulin Resistance 3018 100.00 Very High Very High Very High
Impaired Glucose Tolerance 957 100.00 Very High Very High Very High
Body Weight 739 100.00 Very High Very High Very High
Weight Gain 717 100.00 Very High Very High Very High
Hyperinsulinism 596 100.00 Very High Very High Very High
Stress 582 100.00 Very High Very High Very High
Nicotine Addiction 349 100.00 Very High Very High Very High
Cv Unclassified Under Development 190 100.00 Very High Very High Very High
Cv General 3 Under Development 147 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin sensitivity was highest in chronic pancreatitis patients before surgery (p < 0.01), but remained unchanged by the partial pancreatectomy.
Regulation (sensitivity) of Insulin
1) Confidence 0.62 Published 2009 Journal Diabetologia Section Body Doc Link 19037627 Disease Relevance 0 Pain Relevance 0
Acupuncture-induced changes in human plasma insulin level.
Regulation (changes) of insulin in plasma associated with acupuncture
2) Confidence 0.62 Published 1984 Journal Acupunct Electrother Res Section Title Doc Link 6145307 Disease Relevance 0 Pain Relevance 0.30
No patient received any medication that could affect VMA measurement, such as insulin, reserpine, norepineprine, epineprine, morphine, or pentobarbital.
Regulation (affect) of insulin associated with morphine
3) Confidence 0.62 Published 2004 Journal Crit Care Section Body Doc Link PMC420062 Disease Relevance 0.09 Pain Relevance 0.10
The systems differ in the formulation of the inhaled insulin – liquid vs lyophilized powder – and the delivery device with respect to size, mechanism of insulin release, and regulation of insulin administration (mechanical vs electronic).
Regulation (regulation) of insulin
4) Confidence 0.62 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.05 Pain Relevance 0.08
When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon.
Neg (no) Regulation (effect) of insulin in plasma associated with morphine
5) Confidence 0.62 Published 1986 Journal Diabetes Section Abstract Doc Link 3512343 Disease Relevance 0 Pain Relevance 0.50
Moreover in obese patients we evaluated the effect of this anti-opioid drug on insulin secretion and insulin sensitivity during an IVGTT using the minimal model approach.
Regulation (sensitivity) of insulin associated with obesity and opioid
6) Confidence 0.61 Published 1994 Journal Horm. Metab. Res. Section Abstract Doc Link 8082873 Disease Relevance 0.41 Pain Relevance 0.36
The ideal closed-loop system, or “artificial pancreas,” should contain three basic elements [95]:

Additionally, the microcomputer system in an artificial pancreas will sample, filter, and interpret the glucose sensor data, to compare the reading with allowable norms and to accurately control insulin in order to achieve normalized blood glucose levels.

Regulation (control) of insulin in blood
7) Confidence 0.61 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0.31 Pain Relevance 0
Insulin sensitivity was greatly impaired by anesthesia with isoflurane, but was not affected by use of the anxiolytic agent diazepam.
Regulation (sensitivity) of Insulin associated with anesthesia, anxiety disorder and isoflurane
8) Confidence 0.61 Published 2003 Journal Comp. Med. Section Abstract Doc Link 12625507 Disease Relevance 1.27 Pain Relevance 0.24
Changes in islet B-cell dysfunction were assessed through changes in proinsulin, C-peptide and proinsulin:C-peptide ratio.
Regulation (changes) of proinsulin in B-cell
9) Confidence 0.60 Published 2007 Journal Diabetic Medicine Section Body Doc Link PMC1974817 Disease Relevance 0.33 Pain Relevance 0
Changes in islet B-cell dysfunction were assessed through changes in proinsulin, C-peptide and proinsulin:C-peptide ratio.
Regulation (changes) of proinsulin in B-cell
10) Confidence 0.60 Published 2007 Journal Diabetic Medicine Section Body Doc Link PMC1974817 Disease Relevance 0.32 Pain Relevance 0
These mutations affect proinsulin biosynthesis per se and function as null mutations, doing so by several different mechanisms.
Regulation (affect) of proinsulin
11) Confidence 0.60 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.31 Pain Relevance 0
Plasma aldosterone increased and insulin levels did not change during the procedures, and these levels were lower than in younger adults.
Neg (not) Regulation (change) of insulin in Plasma
12) Confidence 0.58 Published 1980 Journal Can Anaesth Soc J Section Abstract Doc Link 7013944 Disease Relevance 0 Pain Relevance 0.04
Many anesthetics differently affect plasma glucose and insulin levels, with minor effects on plasma FFA.
Regulation (affect) of insulin in plasma
13) Confidence 0.58 Published 2008 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2329728 Disease Relevance 0.20 Pain Relevance 0.19
Influence of insulin on cerebral metabolism
Regulation (Influence) of insulin
14) Confidence 0.56 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0 Pain Relevance 0.22
R in the control of body composition and insulin sensitivity has not been explored in detail in the published literature.
Regulation (control) of insulin in body
15) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.15 Pain Relevance 0
Fasting insulin sensitivity was not affected by diet (QUICKI = 0.66 ± 0.15 vs. 0.70 ± 0.36, Paleolithic vs.
Neg (not) Regulation (affected) of insulin
16) Confidence 0.52 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1635051 Disease Relevance 0 Pain Relevance 0
Furthermore, contrary to our survey in humans [24], this finding of higher insulin sensitivity was associated with no significant difference between groups in fasting levels of insulin and glucose, indicating that the Paleolithic diet affected insulin action mainly at the level of muscle and adipose tissues rather than the liver [18].
Regulation (affected) of insulin in muscle
17) Confidence 0.52 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1635051 Disease Relevance 0.44 Pain Relevance 0.10
Patients who had used glucocorticoids within the previous 2 months or who were taking agents known to affect insulin sensitivity or lipid metabolism were excluded.
Regulation (affect) of insulin
18) Confidence 0.52 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30711 Disease Relevance 1.59 Pain Relevance 0.85
The antilipolytic effects of both the alpha 2-agonist clonidine and insulin were unaffected by exercise.
Neg (unaffected) Regulation (unaffected) of insulin associated with agonist and clonidine
19) Confidence 0.50 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2821823 Disease Relevance 0.25 Pain Relevance 0.39
In these subjects, it is possible to find increased concentrations of glycosylated hemoglobin A1 and a marked reduction of the acute insulin response to intravenous glucose, but not to arginine, which suggests a state of defective glucose recognition by pancreatic beta-cells during narcotic addiction.
Regulation (response) of insulin associated with addiction, hyperinsulinism and opiate addiction
20) Confidence 0.50 Published 1984 Journal Diabetes Care Section Abstract Doc Link 6368156 Disease Relevance 0.36 Pain Relevance 0.58

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