INT251001

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
regulatory T cells 2
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 39 89.36 High High
Nerve growth factor 49 86.08 High High
Inflammation 15 68.28 Quite High
Neuropeptide 1 49.60 Quite Low
substance P 8 47.84 Quite Low
chemokine 1 34.80 Quite Low
Pain 4 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 108 100.00 Very High Very High Very High
Disease 16 89.12 High High
Recurrence 22 88.48 High High
INFLAMMATION 14 68.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 67.12 Quite High
Neurogenic Inflammation 2 53.20 Quite High
Leishmaniasis 33 43.68 Quite Low
Necrosis 2 32.36 Quite Low
Cancer 2 32.00 Quite Low
Bacterial Infection 1 25.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding corroborates with the relatively reduced suppression of IFN-?
Negative_regulation (reduced) of Negative_regulation (suppression) of IFN
1) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.20 Pain Relevance 0.10
Negligible decline in plasma IL-12 and IL-10 levels, negligible elevation of IFN-?
Negative_regulation (decline) of Negative_regulation (elevation) of IFN in plasma
2) Confidence 0.41 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.23 Pain Relevance 0.04
Fig. 7 shows schematically the action mechanism of FoxP3+CD25+CD4+ regulatory T cells, which are conceivable to suppress the induction and exacerbation of AD-like lesions through the suppression of IFN-?
Negative_regulation (suppress) of Negative_regulation (suppression) of IFN in regulatory T cells associated with eczema
3) Confidence 0.41 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.78 Pain Relevance 0.22

General Comments

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