INT251026

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.02
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
respiratory 6
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 80.60 Quite High
Inflammatory response 3 79.08 Quite High
cytokine 8 76.76 Quite High
corticosteroid 12 64.12 Quite High
melanocortin 1 receptor 158 63.76 Quite High
Bile 12 5.00 Very Low Very Low Very Low
backache 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 18 100.00 Very High Very High Very High
Acute Renal Failure 6 100.00 Very High Very High Very High
Retinoblastoma 2 100.00 Very High Very High Very High
Disseminated Intravascular Coagulation 18 99.92 Very High Very High Very High
Necrosis 13 98.08 Very High Very High Very High
Cancer 15 90.64 High High
Communicable Diseases 3 89.20 High High
Aging 62 88.68 High High
Melanoma 154 88.56 High High
Streptococcus Infection 24 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This protein is known to inhibit the cyclin-dependent kinase 4 (CDK4)–mediated phosphorylation of retinoblastoma 1 protein and prevents the cell from progressing through the G1 cell cycle checkpoint (3,4).
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of CDK4 associated with retinoblastoma
1) Confidence 0.42 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.17 Pain Relevance 0.12
Moreover, we demonstrate a correlation between caveolin-1 and p16INK4a gene expression. p16INK4a is a cyclin-dependent kinase inhibitor that prevents retinoblastoma phosphorylation and arrests the cell cycle in the G0/G1 phase prior to entry into the synthesis phase [53,54].
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of p16INK4a associated with retinoblastoma
2) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.93 Pain Relevance 0.05
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
Negative_regulation (syndrome) of Phosphorylation (alkaline phosphatase) of ARF in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
3) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.97 Pain Relevance 0.15
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
Negative_regulation (tomography) of Phosphorylation (alkaline phosphatase) of ARF in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
4) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.98 Pain Relevance 0.15
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
Negative_regulation (failure) of Phosphorylation (alkaline phosphatase) of ARF in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
5) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.97 Pain Relevance 0.15

General Comments

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