INT25104

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.44
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ptz1a (Mus musculus)
Pain Link Frequency Relevance Heat
anticonvulsant 10 99.98 Very High Very High Very High
addiction 3 99.90 Very High Very High Very High
Morphine 5 99.68 Very High Very High Very High
Clonidine 8 99.08 Very High Very High Very High
GABAergic 15 97.64 Very High Very High Very High
gABA 37 97.04 Very High Very High Very High
Neurotransmitter 2 96.48 Very High Very High Very High
Kappa opioid receptor 3 93.20 High High
agonist 5 92.52 High High
Intracerebroventricular 3 84.64 Quite High
Disease Link Frequency Relevance Heat
Convulsion 32 99.96 Very High Very High Very High
Hypokinesia 4 95.04 Very High Very High Very High
Epilepsy 11 89.04 High High
Attention Deficit Hyperactivity Disorder 7 88.88 High High
Panic Disorder 2 75.00 Quite High
Disease 2 5.00 Very Low Very Low Very Low
Myoclonus 2 5.00 Very Low Very Low Very Low
Coma 1 5.00 Very Low Very Low Very Low
Muscular Spasm 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of PTZ 1 or 2 weeks prior to clonidine cannot be explained as simply due to a lingering impairment of locomotion by PTZ, since no hypokinesia was observed when activity in these groups was examined immediately prior to clonidine administration.
Regulation (influence) of PTZ associated with hypokinesia and clonidine
1) Confidence 0.38 Published 1989 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2498966 Disease Relevance 0.41 Pain Relevance 0.67
It is concluded that morphine-dependence may modulate PTZ-kindling and seizure susceptibility in rats with emphasis on the role of GABA and NMDA neurotransmitter systems.
Regulation (modulate) of PTZ associated with addiction, neurotransmitter, gaba, convulsion and morphine
2) Confidence 0.09 Published 2000 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 11115738 Disease Relevance 0.77 Pain Relevance 0.64
Therefore, menthol has an anticonvulsant effect in the PTZ mouse model, presumably through its potentiation on tonic GABAergic inhibition.
Regulation (effect) of PTZ associated with gabaergic and anticonvulsant
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2560999 Disease Relevance 0.72 Pain Relevance 0.31
Ena injected i.c.v. in doses of 1 and 10 nmol did not affect acute PTZ seizures.
Neg (not) Regulation (affect) of PTZ associated with convulsion
4) Confidence 0.01 Published 1999 Journal Brain Res. Section Abstract Doc Link 10095026 Disease Relevance 0.53 Pain Relevance 0.38

General Comments

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