INT251053

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Wnt3a) extracellular space (Wnt3a) extracellular region (Wnt3a)
proteinaceous extracellular matrix (Wnt3a) plasma membrane (Wnt3a) extracellular matrix organization (Wnt3a)
Wnt3a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 99 95.44 Very High Very High Very High
Cancer 74 74.32 Quite High
Coronary Artery Disease 6 74.00 Quite High
Sarcoma 3 52.28 Quite High
Breast Cancer 12 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 9 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low
Glioma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Passaged MBEs were cultured for 6 d in either control or conditioned medium (CM) of L cells, producing Wnt3a, which acts through ?
Gene_expression (producing) of Wnt3a
1) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0.07 Pain Relevance 0
PLD activity was required to increase formation of the complex and Wnt3a target gene expression.
Gene_expression (expression) of Wnt3a
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.20 Pain Relevance 0
Moreover, depletion of PLD1 or 2 blocked expression of Wnt3a-induced target genes, including c-Myc, Cyclin D1, NOS2, and vimentin (Figure 5B).
Gene_expression (expression) of Wnt3a
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.06 Pain Relevance 0
Depletion of PLD1 or 2 suppressed Wnt3a-induced migratory and invasive activity (Figure 6A and B).
Gene_expression (suppressed) of Wnt3a
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.17 Pain Relevance 0

General Comments

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