INT251078

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.10
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (G0s2)
Anatomy Link Frequency
lipid droplets 2
lymphocytes 2
G0s2 (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 8 100.00 Very High Very High Very High
pain pelvic 8 100.00 Very High Very High Very High
rheumatoid arthritis 88 96.96 Very High Very High Very High
agonist 30 96.00 Very High Very High Very High
psoriasis 16 95.28 Very High Very High Very High
ischemia 16 73.44 Quite High
Inflammation 54 65.36 Quite High
Inflammatory mediators 9 60.72 Quite High
corticosteroid 8 44.88 Quite Low
cytokine 16 27.76 Quite Low
Disease Link Frequency Relevance Heat
Aging 16 100.00 Very High Very High Very High
Reprotox - General 3 16 100.00 Very High Very High Very High
Endometriosis (extended) 8 100.00 Very High Very High Very High
Targeted Disruption 216 99.78 Very High Very High Very High
Autoimmune Disease 128 98.44 Very High Very High Very High
Systemic Lupus Erythematosus 96 98.40 Very High Very High Very High
Obesity 14 97.24 Very High Very High Very High
Rheumatoid Arthritis 88 96.96 Very High Very High Very High
Vasculitis 704 96.72 Very High Very High Very High
Psoriasis 16 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preparation of transgenic mice that overexpress G0S2
Positive_regulation (overexpress) of Gene_expression (overexpress) of G0S2 associated with targeted disruption
1) Confidence 0.69 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.50 Pain Relevance 0
To explore the physiological significance of G0S2, we prepared transgenic mice that overexpress the human gene for G0S2.
Positive_regulation (overexpress) of Gene_expression (overexpress) of G0S2 associated with targeted disruption
2) Confidence 0.69 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.58 Pain Relevance 0
Notably, relative to healthy controls, G0S2 expression is also enhanced in the PBMCs from patients with other autoimmune diseases, namely SLE4 and RA.5 Microarray and qRT–PCR analyses also showed that G0S2 is upregulated in the PBMCs from psoriasis patients suffering from severe generalized disease.13 Thus, it may be interesting to analyze G0S2 further, as it may shed light on the pathogenesis of vasculitis at the molecular level (see below).
Positive_regulation (enhanced) of Gene_expression (expression) of G0S2 associated with psoriasis, autoimmune disease, rheumatoid arthritis, vasculitis and disease
3) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.23 Pain Relevance 0.13
Of these genes, we analyzed G0/G1 switch gene 2 (G0S2) further because G0S2 expression is also enhanced in the PBMCs of patients with systemic lupus erythematodes (SLE).
Positive_regulation (enhanced) of Spec (analyzed) Gene_expression (expression) of G0S2 associated with systemic lupus erythematosus
4) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Abstract Doc Link PMC2575881 Disease Relevance 1.07 Pain Relevance 0
Thus, the exogenous and ubiquitous overexpression of human G0S2 seems to make the transgenic mice unhealthy and inhibits their production of offspring.


Positive_regulation (overexpression) of Gene_expression (overexpression) of G0S2 associated with targeted disruption
5) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.05 Pain Relevance 0
It will be necessary to study larger numbers of G0S2-TG mice to confirm this association between G0S2 overexpression and the development of autoimmune features.
Positive_regulation (overexpression) of Gene_expression (overexpression) of G0S2
6) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.83 Pain Relevance 0.03
G0S2 was first identified as one of the G0/G1 switch (G0S) genes that are differentially expressed in lymphocytes during their lectin-induced switch from the G0 to the G1 phases of the cell cycle.20 G0S2 is one of the genes that is upregulated during normal implantation but its expression is significantly lower in women with endometriosis that is associated with pelvic pain and infertility with implantation failure.21 In a replicative senescence model employing human dermal fibroblasts (HDF), G0S2 expression was upregulated in old HDF cells, which suggests that it participates in senescence.22 Microarray and qRT–PCR analyses of PBMCs from psoriasis patients suffering from severe generalized disease also revealed the upregulation of G0S2.13 Moreover, we showed previously that G0S2 mRNA levels are markedly increased in the PBMCs from patients with the autoimmune diseases SLE4 and RA.5 G0S2 is a putative target gene of peroxisome-proliferator-activated receptor (PPAR) alpha, which belongs to a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis.
Positive_regulation (upregulated) of Gene_expression (expression) of G0S2 in lymphocytes associated with psoriasis, autoimmune disease, aging, rheumatoid arthritis, disease, endometriosis, reprotox - general 3 and pain pelvic
7) Confidence 0.40 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.41 Pain Relevance 0.27
We generated G0S2 transgenic mice that ubiquitously overexpress human G0S2.
Positive_regulation (overexpress) of Gene_expression (overexpress) of G0S2 associated with targeted disruption
8) Confidence 0.40 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Abstract Doc Link PMC2575881 Disease Relevance 1.05 Pain Relevance 0
Interestingly, the G(0)/G(1) switch gene 2 (G0s2) was recently identified as an inhibitor of Pnpla2 activity and located to lipid droplets in adipocytes stimulated with ?
Positive_regulation (recently) of Gene_expression (identified) of G0s2 in lipid droplets associated with obesity
9) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.39 Pain Relevance 0.13

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