INT251079

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 36.32
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (G0s2)
Anatomy Link Frequency
lipid droplets 2
lymphocytes 2
macrophages 1
monocytes 1
section 3 1
G0s2 (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 33 100.00 Very High Very High Very High
pain pelvic 33 100.00 Very High Very High Very High
rheumatoid arthritis 363 96.28 Very High Very High Very High
agonist 60 96.00 Very High Very High Very High
psoriasis 66 94.64 High High
cytokine 66 76.20 Quite High
ischemia 66 73.44 Quite High
Inflammatory mediators 35 68.68 Quite High
Inflammation 193 65.36 Quite High
corticosteroid 33 44.88 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 891 100.00 Very High Very High Very High
Aging 66 100.00 Very High Very High Very High
Reprotox - General 3 66 100.00 Very High Very High Very High
Endometriosis (extended) 33 100.00 Very High Very High Very High
Vasculitis 2904 99.40 Very High Very High Very High
Obesity 28 98.64 Very High Very High Very High
Systemic Lupus Erythematosus 396 97.80 Very High Very High Very High
Autoimmune Disease 528 97.76 Very High Very High Very High
Cytomegalovirus Infection 99 96.84 Very High Very High Very High
Rheumatoid Arthritis 363 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preparation of transgenic mice that overexpress G0S2
Gene_expression (overexpress) of G0S2 associated with targeted disruption
1) Confidence 0.77 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.50 Pain Relevance 0
To examine the expression patterns of exogenous human G0S2 in various transgenic mouse tissues, we first performed ISH analysis.
Spec (examine) Gene_expression (expression) of G0S2 associated with targeted disruption
2) Confidence 0.77 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.95 Pain Relevance 0
For this purpose, we constructed plasmid DNA in which human G0S2 cDNA lies directly downstream of the beta-actin promoter, as described previously.7 This construct was used to generate transgenic mouse lines that express human G0S2 protein in all tissues.
Gene_expression (express) of G0S2 protein associated with targeted disruption
3) Confidence 0.77 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.65 Pain Relevance 0
Immunohistochemical analysis using the monoclonal antibody (#3-1) also detected exogenously expressed human G0S2 proteins in various organs and tissues of the transgenic mice.
Gene_expression (expressed) of G0S2 associated with targeted disruption
4) Confidence 0.77 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.55 Pain Relevance 0
It will be necessary to study larger numbers of G0S2-TG mice to confirm this association between G0S2 overexpression and the development of autoimmune features.
Gene_expression (overexpression) of G0S2
5) Confidence 0.77 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.83 Pain Relevance 0.03
To explore the physiological significance of G0S2, we prepared transgenic mice that overexpress the human gene for G0S2.
Gene_expression (overexpress) of G0S2 associated with targeted disruption
6) Confidence 0.77 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.58 Pain Relevance 0
In the kidney, although most urinary tubule epithelia were weakly positive for G0S2, other epithelia expressed this protein at high levels; the latter epithelia also existed in clumps (Fig. 6Di).
Gene_expression (positive) of G0S2 in tubule
7) Confidence 0.66 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.51 Pain Relevance 0
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (early) of G0S2 associated with vasculitis
8) Confidence 0.66 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.16 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (symptoms) of G0S2 associated with vasculitis
9) Confidence 0.66 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.17 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (delta) of G0S2 associated with vasculitis
10) Confidence 0.66 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.11 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (symptoms) of G0/G1 switch gene 2 associated with vasculitis
11) Confidence 0.65 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.16 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (early) of G0/G1 switch gene 2 associated with vasculitis
12) Confidence 0.65 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.15 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (delta) of G0/G1 switch gene 2 associated with vasculitis
13) Confidence 0.65 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.13 Pain Relevance 0.10
In addition, the surviving male mouse GTG1b only produced male transgenic mice when mated with wild-type B6 female mice because the human G0S2 gene was introduced into the Y chromosome.
Gene_expression (introduced) of G0S2 gene associated with targeted disruption
14) Confidence 0.59 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.90 Pain Relevance 0
Human G0S2 expression patterns in transgenic mice
Gene_expression (expression) of G0S2 associated with targeted disruption
15) Confidence 0.59 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.02 Pain Relevance 0
G0S2 was first identified as one of the G0/G1 switch (G0S) genes that are differentially expressed in lymphocytes during their lectin-induced switch from the G0 to the G1 phases of the cell cycle.20 G0S2 is one of the genes that is upregulated during normal implantation but its expression is significantly lower in women with endometriosis that is associated with pelvic pain and infertility with implantation failure.21 In a replicative senescence model employing human dermal fibroblasts (HDF), G0S2 expression was upregulated in old HDF cells, which suggests that it participates in senescence.22 Microarray and qRT–PCR analyses of PBMCs from psoriasis patients suffering from severe generalized disease also revealed the upregulation of G0S2.13 Moreover, we showed previously that G0S2 mRNA levels are markedly increased in the PBMCs from patients with the autoimmune diseases SLE4 and RA.5 G0S2 is a putative target gene of peroxisome-proliferator-activated receptor (PPAR) alpha, which belongs to a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis.
Gene_expression (expression) of G0S2 in lymphocytes associated with psoriasis, autoimmune disease, aging, rheumatoid arthritis, disease, endometriosis, reprotox - general 3 and pain pelvic
16) Confidence 0.59 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.12 Pain Relevance 0.24
Thus, the exogenous and ubiquitous overexpression of human G0S2 seems to make the transgenic mice unhealthy and inhibits their production of offspring.


Gene_expression (overexpression) of G0S2 associated with targeted disruption
17) Confidence 0.59 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.05 Pain Relevance 0
For example, in the first attempt to generate this line, 61 mice were tested by PCR for expression of human G0S2.
Gene_expression (expression) of G0S2
18) Confidence 0.59 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.71 Pain Relevance 0
Expression of G0S2 protein was confirmed by the monoclonal antibody (#3-1) we prepared here (see Supplementary Result and Fig.
Gene_expression (Expression) of G0S2 protein
19) Confidence 0.59 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.64 Pain Relevance 0
We previously reported that G0S2 was primarily expressed in monocytes, whereas Amphiregulin was expressed in both monocytes, T cells and B cells by performing RT–PCR on multiple-tissue cDNA panels (MTC) from Clontech (Palo Alto, CA).5 To determine whether EGR1, HBD, TVAS10, IL1R2, and calgranulin C are also expressed in particular human blood cells, we conducted similar experiments.
Gene_expression (expressed) of G0S2 in monocytes
20) Confidence 0.59 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.49 Pain Relevance 0.07

General Comments

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