INT251080

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 8.16
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Areg) nucleus (Areg) intracellular (Areg)
cytoplasm (Areg)
Anatomy Link Frequency
monocytes 1
Areg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 45 97.48 Very High Very High Very High
rheumatoid arthritis 44 90.92 High High
cytokine 8 74.16 Quite High
ischemia 8 5.00 Very Low Very Low Very Low
psoriasis 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
endometriosis 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
pain pelvic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 352 99.40 Very High Very High Very High
Cleidocranial Dysplasia 12 98.04 Very High Very High Very High
INFLAMMATION 45 97.48 Very High Very High Very High
Colitis 67 93.48 High High
Rheumatoid Vasculitis 4 92.08 High High
Rheumatoid Arthritis 44 90.92 High High
Malignant Neoplastic Disease 4 90.80 High High
Churg-strauss Syndrome 12 90.32 High High
Cancer 47 90.08 High High
Increased Venous Pressure Under Development 24 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (early) of amphiregulin associated with vasculitis
1) Confidence 0.60 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.17 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (symptoms) of amphiregulin associated with vasculitis
2) Confidence 0.60 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.18 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (delta) of amphiregulin associated with vasculitis
3) Confidence 0.60 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.10 Pain Relevance 0.10
We previously reported that G0S2 was primarily expressed in monocytes, whereas Amphiregulin was expressed in both monocytes, T cells and B cells by performing RT–PCR on multiple-tissue cDNA panels (MTC) from Clontech (Palo Alto, CA).5 To determine whether EGR1, HBD, TVAS10, IL1R2, and calgranulin C are also expressed in particular human blood cells, we conducted similar experiments.
Gene_expression (expressed) of Amphiregulin in monocytes
4) Confidence 0.54 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.43 Pain Relevance 0.07
Mucosal Cox-2 and amphiregulin (AR) expression, prostanoid synthesis, and EGFR activation were analyzed.


Gene_expression (expression) of amphiregulin
5) Confidence 0.31 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2912804 Disease Relevance 1.28 Pain Relevance 0.05

General Comments

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