INT251126

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.56
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg2) cytoplasm (Dlg2)
Anatomy Link Frequency
neuronal 1
neurons 1
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 154 99.08 Very High Very High Very High
Lasting pain 16 98.28 Very High Very High Very High
Dorsal horn 24 98.20 Very High Very High Very High
tolerance 50 97.12 Very High Very High Very High
Physical dependence 30 96.56 Very High Very High Very High
Glutamate receptor 2 95.76 Very High Very High Very High
Central nervous system 22 95.24 Very High Very High Very High
potassium channel 2 94.52 High High
Analgesic 28 88.28 High High
Opioid 16 83.04 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 102 99.54 Very High Very High Very High
Pain 36 97.84 Very High Very High Very High
Drug Dependence 30 96.56 Very High Very High Very High
Cerebellar Diseases 2 38.32 Quite Low
Hypersensitivity 6 6.52 Low Low
Substance Withdrawal Syndrome 8 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Pathologic Processes 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the detailed mechanism through which PSD-93 deficiency affects the development of neuronal plasticity in persistent pain and morphine tolerance and physical dependence remains to be explored.
Regulation (affects) of PSD-93 in neuronal associated with pain, physical dependence, lasting pain, tolerance and morphine
1) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.81 Pain Relevance 1.22
Blunted NMDAR-dependent neuronal plasticity following repeated morphine injection in PSD-93 KO mice is attributed to PSD-93 deletion-induced alterations of NR2A and NR2B postsynaptic expression in dorsal horn and forebrain cortex neurons, but not in cerebellar neurons.
Regulation (alterations) of PSD-93 in neurons associated with targeted disruption, dorsal horn and morphine
2) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.75 Pain Relevance 1.24

General Comments

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