INT251128

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.97
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg2) cytoplasm (Dlg2)
Anatomy Link Frequency
cerebellum 2
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Physical dependence 30 99.68 Very High Very High Very High
tolerance 50 98.72 Very High Very High Very High
Morphine 154 98.32 Very High Very High Very High
Pain 12 98.08 Very High Very High Very High
Lasting pain 16 97.80 Very High Very High Very High
Central nervous system 22 97.52 Very High Very High Very High
Spinal cord 16 96.88 Very High Very High Very High
Opioid 16 95.12 Very High Very High Very High
Dorsal horn 24 83.44 Quite High
Analgesic 28 70.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 102 100.00 Very High Very High Very High
Drug Dependence 30 99.68 Very High Very High Very High
Pain 36 98.08 Very High Very High Very High
Pathologic Processes 4 97.08 Very High Very High Very High
Cerebellar Diseases 2 95.60 Very High Very High Very High
Hypersensitivity 6 63.80 Quite High
Nociception 2 50.72 Quite High
Nervous System Injury 2 47.24 Quite Low
Substance Withdrawal Syndrome 8 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we examined whether PSD-93 deficiency affected synaptic NR2A and NR2B expression in two major pain-related regions [18,19], spinal cord and forebrain cortex, and a motor and coordination-related region [20], cerebellum, of the CNS.
Spec (whether) Regulation (affected) of Spec (whether) Negative_regulation (deficiency) of PSD-93 in cerebellum associated with pain, central nervous system and spinal cord
1) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.74 Pain Relevance 0.52
Thus, targeted disruption of PSD-93 or perturbing NMDAR-PSD-93 interaction might be a better strategy for prevention and/or treatment of persistent pain and opioid tolerance and physical dependence in clinic.
Regulation (targeted) of Negative_regulation (disruption) of PSD-93 associated with pain, targeted disruption, physical dependence, lasting pain, tolerance and opioid
2) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 1.22 Pain Relevance 1.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox