INT251134

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.26
Pain Relevance 5.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg2) cytoplasm (Dlg2)
Anatomy Link Frequency
postsynaptic membrane 1
spinal cord 1
forebrain 1
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 40 99.28 Very High Very High Very High
Physical dependence 75 98.76 Very High Very High Very High
potassium channel 6 98.00 Very High Very High Very High
tolerance 125 97.80 Very High Very High Very High
Lasting pain 40 97.48 Very High Very High Very High
Morphine 385 97.40 Very High Very High Very High
Analgesic 70 96.96 Very High Very High Very High
Opioid 40 96.68 Very High Very High Very High
Glutamate receptor 14 93.60 High High
Pain 31 90.88 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 261 99.92 Very High Very High Very High
Drug Dependence 76 98.76 Very High Very High Very High
Pain 91 97.04 Very High Very High Very High
Cerebellar Diseases 5 94.68 High High
Nervous System Injury 5 73.60 Quite High
Nociception 5 66.56 Quite High
Hypersensitivity 15 62.88 Quite High
Schizophrenia 13 50.00 Quite Low
Adhesions 1 22.40 Low Low
Substance Withdrawal Syndrome 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, targeted disruption of PSD-93 or perturbing NMDAR-PSD-93 interaction might be a better strategy for prevention and/or treatment of persistent pain and opioid tolerance and physical dependence in clinic.
PSD-93 Binding (interaction) of associated with pain, targeted disruption, physical dependence, lasting pain, tolerance and opioid
1) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 1.17 Pain Relevance 1.48
Besides NMDARs and nNOS, PSD-93 binds to other postsynaptic membrane proteins, such as potassium channels [9,10], ?
PSD-93 Binding (binds) of in postsynaptic membrane associated with potassium channel
2) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.97 Pain Relevance 1.37
These findings demonstrate PSD-93 binding to NMDARs in the spinal cord and forebrain cortex in vivo.
PSD-93 Binding (binding) of in spinal cord associated with spinal cord
3) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.48 Pain Relevance 0.84
Thus, targeted disruption of PSD-93 or perturbing NMDAR-PSD-93 interaction might be a better strategy for prevention and/or treatment of persistent pain and opioid tolerance and physical dependence in clinic.
NMDAR-PSD-93 Binding (interaction) of associated with pain, targeted disruption, physical dependence, lasting pain, tolerance and opioid
4) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 1.16 Pain Relevance 1.46
These findings demonstrate PSD-93 binding to NMDARs in the spinal cord and forebrain cortex in vivo.
PSD-93 Binding (binding) of in forebrain associated with spinal cord
5) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.48 Pain Relevance 0.84
This peptide affinity method was not specific to PSD-95 as the peptides are known to bind PSD-93 and SAP102 (Lim et al, 2002; Chung et al, 2004).
PSD-93 Binding (bind) of
6) Confidence 0.09 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0

General Comments

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