INT251142

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4, Grin2a) transport (Grin2a) structural molecule activity (Dlg4)
locomotion (Grin2a) protein complex assembly (Dlg4) cytoplasm (Dlg4)
Dlg4 (Mus musculus)
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 64 99.24 Very High Very High Very High
Central nervous system 16 96.88 Very High Very High Very High
Hippocampus 27 91.64 High High
Glutamate receptor 5 87.68 High High
Dynorphin 2 84.60 Quite High
Spinal cord 8 84.24 Quite High
opiate 1 81.36 Quite High
Pain 7 80.48 Quite High
Dorsal horn 12 76.28 Quite High
Dorsal horn neuron 1 71.04 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 72 84.96 Quite High
Pain 21 80.48 Quite High
Depression 31 59.84 Quite High
Anxiety Disorder 24 59.20 Quite High
Drug Dependence 16 50.00 Quite Low
Substance Withdrawal Syndrome 4 21.52 Low Low
Shock 9 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of PSD95 with NR2 subunit was implicated in NMDA receptor trafficking and function on the cell membrane.
PSD95 Binding (Binding) of NR2 subunit associated with nmda receptor
1) Confidence 0.30 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.17 Pain Relevance 0.65
PSD-95 and SAP102, two members of the MAGUK family of proteins, also interact with NR2A and NR2B [13,32].
PSD-95 Binding (interact) of NR2A
2) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.32 Pain Relevance 0.54
As predicted both by the interaction between PSD-95 and the NR2 subunits of the NMDAR [28], and by the binding of Neto1 to PSD-95 described above, we found that Neto1 was co-immunoprecipitated by anti-NR1 antibodies from lysates of cells co-expressing Neto1, PSD-95, NR1, and NR2B (Figure 4A, lane 1).
PSD-95 Binding (interaction) of NR2
3) Confidence 0.11 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox