INT251145

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.30
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2a, Dlg2) transport (Grin2a) locomotion (Grin2a)
cytoplasm (Dlg2)
Anatomy Link Frequency
synapses 1
Grin2a (Mus musculus)
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 55 98.24 Very High Very High Very High
Morphine 385 90.20 High High
Dorsal horn 60 87.20 High High
Lasting pain 40 82.16 Quite High
withdrawal 115 74.28 Quite High
narcan 30 73.32 Quite High
Dorsal horn neuron 5 63.36 Quite High
Physical dependence 75 62.80 Quite High
tolerance 125 61.84 Quite High
Opioid 40 61.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 255 94.16 High High
Pain 90 81.28 Quite High
Substance Withdrawal Syndrome 20 74.64 Quite High
Drug Dependence 75 62.80 Quite High
Pathologic Processes 10 60.64 Quite High
INFLAMMATION 10 33.60 Quite Low
Hyperalgesia 15 9.20 Low Low
Neuropathic Pain 15 8.20 Low Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Cerebellar Diseases 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deletion of PDZ domains from PSD-93 not only disrupts interaction between NR2A/NR2B and PSD-93, but also reduces NMDAR clustering at cellular membranes in vitro [10].
NR2A Binding (interaction) of PSD-93
1) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.44 Pain Relevance 0.32
The deletion of PDZ domains from PSD-93 not only disrupts interaction between NR2A/NR2B and PSD-93, but also reduces NMDAR clustering at cellular membranes in vitro [10].
NR2A Binding (interaction) of PSD-93
2) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.45 Pain Relevance 0.27
Studies using the yeast two-hybrid system revealed that the PDZ domains of PSD-93 specifically bind to the C-termini of NMDAR subunits NR2A and NR2B [10].
NMDAR subunits NR2A Binding (bind) of PSD-93
3) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.46 Pain Relevance 0.40
Studies using the yeast two-hybrid system revealed that the PDZ domains of PSD-93 specifically bind to the C-termini of NMDAR subunits NR2A and NR2B [10].
NMDAR subunits NR2A Binding (bind) of PSD-93
4) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.46 Pain Relevance 0.40
Evidence from in vitro studies shows that PSD-93 clusters and anchors NMDARs at synapses through interaction of its PDZ domains with seven C-terminal amino acids of NR2A and NR2B [9,10].
NR2A Binding (interaction) of PSD-93 in synapses
5) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.49 Pain Relevance 0.73

General Comments

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