INT251146

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.95
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1, Dlg2) cytoplasm (Grin1, Dlg2) transport (Grin1)
enzyme binding (Grin1)
Anatomy Link Frequency
spinal cord 1
postsynaptic membrane 1
forebrain 1
Grin1 (Mus musculus)
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 24 99.64 Very High Very High Very High
Physical dependence 45 99.00 Very High Very High Very High
tolerance 75 98.04 Very High Very High Very High
potassium channel 3 98.00 Very High Very High Very High
Analgesic 42 97.64 Very High Very High Very High
Morphine 231 97.24 Very High Very High Very High
Lasting pain 24 96.72 Very High Very High Very High
Glutamate receptor 3 93.60 High High
Dorsal horn 36 85.68 High High
Central nervous system 33 77.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 153 99.40 Very High Very High Very High
Drug Dependence 45 99.00 Very High Very High Very High
Pain 54 96.72 Very High Very High Very High
Nervous System Injury 3 74.32 Quite High
Nociception 3 67.28 Quite High
Cerebellar Diseases 3 47.68 Quite Low
Hypersensitivity 9 41.52 Quite Low
Substance Withdrawal Syndrome 12 5.00 Very Low Very Low Very Low
Hyperalgesia 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides NMDARs and nNOS, PSD-93 binds to other postsynaptic membrane proteins, such as potassium channels [9,10], ?
NMDAR Binding (binds) of PSD-93 in postsynaptic membrane associated with potassium channel
1) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.98 Pain Relevance 1.43
These findings demonstrate PSD-93 binding to NMDARs in the spinal cord and forebrain cortex in vivo.
NMDAR Binding (binding) of PSD-93 in spinal cord associated with spinal cord
2) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.48 Pain Relevance 0.86
These findings demonstrate PSD-93 binding to NMDARs in the spinal cord and forebrain cortex in vivo.
NMDAR Binding (binding) of PSD-93 in forebrain associated with spinal cord
3) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.48 Pain Relevance 0.86

General Comments

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