INT251147

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.75
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b, Dlg2) transport (Grin2b) embryo development (Grin2b)
cytoplasm (Dlg2)
Anatomy Link Frequency
synapses 1
Grin2b (Mus musculus)
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 66 98.24 Very High Very High Very High
Morphine 462 90.20 High High
Dorsal horn 72 87.20 High High
Lasting pain 48 82.16 Quite High
withdrawal 138 74.28 Quite High
narcan 36 73.32 Quite High
Dorsal horn neuron 6 64.08 Quite High
Physical dependence 90 62.80 Quite High
tolerance 150 61.84 Quite High
Opioid 48 61.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 306 94.16 High High
Pain 108 81.28 Quite High
Substance Withdrawal Syndrome 24 74.64 Quite High
Drug Dependence 90 62.80 Quite High
Pathologic Processes 12 60.64 Quite High
INFLAMMATION 12 33.60 Quite Low
Hyperalgesia 18 9.20 Low Low
Neuropathic Pain 18 8.20 Low Low
Hypersensitivity 18 5.00 Very Low Very Low Very Low
Cerebellar Diseases 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deletion of PDZ domains from PSD-93 not only disrupts interaction between NR2A/NR2B and PSD-93, but also reduces NMDAR clustering at cellular membranes in vitro [10].
NR2B Binding (interaction) of PSD-93
1) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.45 Pain Relevance 0.27
The deletion of PDZ domains from PSD-93 not only disrupts interaction between NR2A/NR2B and PSD-93, but also reduces NMDAR clustering at cellular membranes in vitro [10].
NR2B Binding (interaction) of PSD-93
2) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.44 Pain Relevance 0.32
The deletion of PDZ domains from PSD-93 not only disrupts interaction between NR2A/NR2B and PSD-93, but also reduces NMDAR clustering at cellular membranes in vitro [10].
NR2B Binding (interaction) of PSD-93
3) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.44 Pain Relevance 0.32
Studies using the yeast two-hybrid system revealed that the PDZ domains of PSD-93 specifically bind to the C-termini of NMDAR subunits NR2A and NR2B [10].
NR2B Binding (bind) of PSD-93
4) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.46 Pain Relevance 0.40
Studies using the yeast two-hybrid system revealed that the PDZ domains of PSD-93 specifically bind to the C-termini of NMDAR subunits NR2A and NR2B [10].
NR2B Binding (bind) of PSD-93
5) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.46 Pain Relevance 0.40
Evidence from in vitro studies shows that PSD-93 clusters and anchors NMDARs at synapses through interaction of its PDZ domains with seven C-terminal amino acids of NR2A and NR2B [9,10].
NR2B Binding (interaction) of PSD-93 in synapses
6) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.49 Pain Relevance 0.73

General Comments

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