INT251148

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2a, Dlg2) transport (Grin2a) locomotion (Grin2a)
cytoplasm (Dlg2)
Grin2a (Mus musculus)
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 12 87.20 High High
Lasting pain 8 82.16 Quite High
Central nervous system 11 58.40 Quite High
Physical dependence 15 57.64 Quite High
tolerance 25 56.68 Quite High
Opioid 8 56.28 Quite High
Morphine 77 50.00 Quite Low
Pain 6 47.28 Quite Low
Spinal cord 8 44.88 Quite Low
nMDA receptor 2 42.28 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 51 94.16 High High
Pain 18 81.28 Quite High
Pathologic Processes 2 60.64 Quite High
Drug Dependence 15 57.64 Quite High
Substance Withdrawal Syndrome 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Cerebellar Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deletion of PDZ domains from PSD-93 not only disrupts interaction between NR2A/NR2B and PSD-93, but also reduces NMDAR clustering at cellular membranes in vitro [10].
Negative_regulation (disrupts) of NR2A Binding (interaction) of PSD-93
1) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.45 Pain Relevance 0.32

General Comments

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