INT251150

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.98
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nos1, Dlg2) cytoplasm (Nos1, Dlg2) cytosol (Nos1)
mitochondrion (Nos1) oxidoreductase activity (Nos1) cytoskeleton (Nos1)
Anatomy Link Frequency
postsynaptic membrane 1
Nos1 (Mus musculus)
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Physical dependence 30 98.56 Very High Very High Very High
potassium channel 2 98.00 Very High Very High Very High
tolerance 50 97.60 Very High Very High Very High
Analgesic 28 97.20 Very High Very High Very High
Morphine 154 96.80 Very High Very High Very High
Lasting pain 16 96.28 Very High Very High Very High
Glutamate receptor 2 93.60 High High
Opioid 16 86.72 High High
Pain 12 72.24 Quite High
Central nervous system 22 60.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 102 98.96 Very High Very High Very High
Drug Dependence 30 98.56 Very High Very High Very High
Pain 36 96.28 Very High Very High Very High
Cerebellar Diseases 2 76.04 Quite High
Hypersensitivity 6 44.24 Quite Low
Nociception 2 31.16 Quite Low
Nervous System Injury 2 27.68 Quite Low
Substance Withdrawal Syndrome 8 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides NMDARs and nNOS, PSD-93 binds to other postsynaptic membrane proteins, such as potassium channels [9,10], ?
nNOS Binding (binds) of PSD-93 in postsynaptic membrane associated with potassium channel
1) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.97 Pain Relevance 1.38
The PDZ domain of nNOS interacts with the PDZ domains of PSD-93 [9].
nNOS Binding (interacts) of PSD-93
2) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 1.01 Pain Relevance 1.25

General Comments

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