INT251163

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.11 Pain Relevance 0.48

cytosol (Alox5, Trpv1) nuclear envelope (Alox5) oxidoreductase activity (Alox5) plasma membrane (Trpv1) nucleus (Alox5) lipid metabolic process (Trpv1)

Alox5 (Rattus norvegicus) Trpv1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Central nervous system 2 96.00 agonist 3 84.08 qutenza 44 81.28 Kinase C 21 71.80 Hyperalgesia 2 56.56 Inflammation 4 56.04 nociceptor 1 54.76 Serotonin 1 52.36 bradykinin 2 50.72 dorsal root ganglion 28 46.96

Disease Link Frequency Relevance Heat Hyperalgesia 3 56.56 INFLAMMATION 4 56.04 Ganglion Cysts 28 46.96 Nociception 3 5.00 Pain 1 5.00 Aids-related Complex 1 5.00 Rupture 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was reported, using single channel studies of inside-out patches, that TRPV1 is activated by several products of lipoxygenase, but minimally by 1-Stearyl-2-arachinonyl-sn-glycerol (SAG), another analog of DAG [7].

Gene_expression (products) of lipoxygenase Positive_regulation (activated) of TRPV1

1) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.11 Pain Relevance 0.48

General Comments

This test has worked.