INT251164

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.44
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Clu, Trpv1) mitochondrion (Clu) endoplasmic reticulum (Clu)
lipid metabolic process (Trpv1) response to stress (Clu) cytoplasm (Clu)
Anatomy Link Frequency
neurons 1
central nervous system 1
Clu (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 8 99.84 Very High Very High Very High
dorsal root ganglion 112 98.52 Very High Very High Very High
qutenza 176 98.40 Very High Very High Very High
agonist 12 90.92 High High
bradykinin 8 90.08 High High
Serotonin 4 86.72 High High
nociceptor 4 82.08 Quite High
Inflammation 16 79.60 Quite High
Kinase C 84 78.64 Quite High
Hyperalgesia 8 78.56 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 112 98.52 Very High Very High Very High
INFLAMMATION 16 79.60 Quite High
Hyperalgesia 12 78.56 Quite High
Rupture 4 28.64 Quite Low
Nociception 12 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Aids-related Complex 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study proposes that DAG is a novel endogenous ligand of TRPV1 and regulates Ca2+ signaling in rat DRG neurons.
DAG Binding (ligand) of TRPV1 in neurons associated with dorsal root ganglion
1) Confidence 0.19 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.26 Pain Relevance 0.80
One plausible mechanism of this pathway is DAG directly interacting with TRPV1.
DAG Binding (interacting) of TRPV1
2) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.48
These results provide strong support for DAG acting as an endogenous ligand for TRPV1.


DAG Binding (ligand) of TRPV1
3) Confidence 0.13 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.39
This result suggested that GPCR-coupled DAG could serve as endogenous ligand of TRPV1 in central nervous system as well as in periphery.
DAG Binding (ligand) of TRPV1 in central nervous system associated with central nervous system
4) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.18 Pain Relevance 0.55

General Comments

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