INT251170

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 2.61
Pain Relevance 6.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Clu, Trpv1) mitochondrion (Clu) endoplasmic reticulum (Clu)
lipid metabolic process (Trpv1) response to stress (Clu) cytoplasm (Clu)
Anatomy Link Frequency
DRG 1
Ovary 1
Clu (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 484 100.00 Very High Very High Very High
TRP channel 55 100.00 Very High Very High Very High
Kinase C 231 99.00 Very High Very High Very High
dorsal root ganglion 308 98.12 Very High Very High Very High
agonist 33 95.80 Very High Very High Very High
Thermal hyperalgesia 11 89.76 High High
antagonist 22 89.36 High High
Central nervous system 22 88.72 High High
Inflammation 44 88.60 High High
Hyperalgesia 22 88.12 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 308 97.64 Very High Very High Very High
Hyperalgesia 33 89.76 High High
INFLAMMATION 44 88.60 High High
Nociception 33 73.24 Quite High
Rupture 11 55.92 Quite High
Pain 11 5.00 Very Low Very Low Very Low
Aids-related Complex 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we examined whether endogenously produced DAG can activate TRPV1 channels.
DAG Positive_regulation (activate) of TRPV1
1) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.06 Pain Relevance 0.10
Therefore, in addition to TRPC3 TRPC6, and TRPC7, which are activated by DAG [21], we demonstrate that TRPV1 is also activated by DAG and other DAG analogues such as OAG, SAG, and DOG.
DAG Positive_regulation (activated) of TRPV1
2) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.19 Pain Relevance 0.58
Mammalian homologues of TRP family (TRPC3, C6 and C7) are activated by DAG [19-21], raising the possibility that DAG directly activates TRPV1.
DAG Positive_regulation (activates) of TRPV1
3) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.61 Pain Relevance 0.59
Another report has provided evidence against direct activation of TRPV1 by DAG in a heterologous system utilizing the Chinese Hamster Ovary (CHO) cell line [21].
DAG Positive_regulation (activation) of TRPV1 in Ovary
4) Confidence 0.19 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.36
In the present study, we found that endogenous DAG produced by GPCR-activation directly activates TRPV1 even in the presence of PKC and DAG lipase inhibitor (Figure 6a).
DAG Positive_regulation (activates) of TRPV1 associated with kinase c
5) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.25 Pain Relevance 0.67
Direct activation of Transient Receptor Potential Vanilloid 1(TRPV1) by Diacylglycerol (DAG)

The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamide, and phosphorylation by protein kinase C (PKC).

DAG Positive_regulation (activation) of TRPV1 associated with kinase c, trp channel and qutenza
6) Confidence 0.16 Published 2008 Journal Mol Pain Section Title Doc Link PMC2576176 Disease Relevance 0.24 Pain Relevance 0.67
Thus, we also tested whether DAG would activate TRPV1 in ?
DAG Spec (whether) Positive_regulation (activate) of TRPV1
7) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.07 Pain Relevance 0.82
Thus, in the present work, we set out to evaluate the possibility of TRPV1 activation by DAG.


DAG Positive_regulation (activation) of TRPV1
8) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.68 Pain Relevance 0.58
Our results consistently support the hypothesis that DAG and its analogs activate TRPV1 directly by binding at the capsaicin-binding site.
DAG Positive_regulation (activate) of TRPV1 associated with qutenza
9) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.87
Here, we report that diacylglycerol (DAG) directly activates TRPV1 channel in a membrane-delimited manner in rat dorsal root ganglion (DRG) neurons. 1-oleoyl-2-acetyl-sn-glycerol (OAG), a membrane-permeable DAG analog, elicited intracellular Ca2+ transients, cationic currents and cobalt uptake that were blocked by TRPV1-selective antagonists, but not by inhibitors of PKC and DAG lipase in rat DRG neurons or HEK 293 cells heterologously expressing TRPV1.
DAG Positive_regulation (activates) of TRPV1 in DRG associated with ganglion cysts, dorsal root ganglion, kinase c and antagonist
10) Confidence 0.16 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2576176 Disease Relevance 0.28 Pain Relevance 0.61
Direct activation of Transient Receptor Potential Vanilloid 1(TRPV1) by Diacylglycerol (DAG)

The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamide, and phosphorylation by protein kinase C (PKC).

DAG Positive_regulation (activation) of TRPV1 associated with kinase c, trp channel and qutenza
11) Confidence 0.14 Published 2008 Journal Mol Pain Section Title Doc Link PMC2576176 Disease Relevance 0.23 Pain Relevance 0.64

General Comments

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