INT25118

Context Info Confidence 0.35 First Reported 1983 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 10 Disease Relevance 0.55 Pain Relevance 5.77

cytoplasm (PLEKHM1)

Anatomy Link Frequency PRP 3 platelet 3 synovial fluid 1 PLEKHM1 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 18 99.98 Paracetamol 65 99.82 agonist 5 96.44 diclofenac 5 95.80 5HT 5 95.12 cINOD 4 89.96 Inflammation 1 84.88 local anesthetic 1 83.24 rheumatoid arthritis 1 75.00 headache 2 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 89.72 Coagulation Disorder 2 81.24 Rheumatoid Arthritis 1 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Most of the drugs used reduced clearly PGE2 and TxB2 levels in synovial fluid, but only a slight diminution in 6-keto-PGF1 alpha values was found.

Negative_regulation (reduced) of TxB2 in synovial fluid

1) Confidence 0.35 Published 1985 Journal Clin. Rheumatol. Section Abstract Doc Link 3864577 Disease Relevance 0.24 Pain Relevance 0.29

We conclude that D-003 at 20 mg/day for 14 days significantly inhibited platelet aggregation to AA and collagen and reduced TxB2 and increased Pgl2 serum levels.

Negative_regulation (reduced) of TxB2 in platelet

2) Confidence 0.05 Published 2004 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 15689052 Disease Relevance 0 Pain Relevance 0

The concentrations of the drugs needed for 50% inhibition of TxB2 generation were 19.0 mumol/l for acetyl-salicylic acid, 0.09 mumol/l for indomethacin, 0.06 mumol/l for diclofenac sodium and 4.2 mumol/l for naproxen sodium.

Negative_regulation (inhibition) of TxB2 associated with diclofenac

3) Confidence 0.05 Published 1983 Journal Prostaglandins Section Abstract Doc Link 6405453 Disease Relevance 0.23 Pain Relevance 0.27

Experimental evidence indicates that inhibition of platelet aggregation induced by D-003 is associated with a reduction of thromboxane B2 (TxB2) and an increase of prostacyclin (Pgl2) serum levels.

Negative_regulation (reduction) of TxB2 in platelet

4) Confidence 0.05 Published 2004 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 15689052 Disease Relevance 0 Pain Relevance 0

At 328 microM PABA the production of TxB2 diminished by 87% (p = 0.013).

Negative_regulation (diminished) of TxB2

5) Confidence 0.04 Published 1997 Journal Thromb. Res. Section Abstract Doc Link 9175234 Disease Relevance 0.08 Pain Relevance 0.20

In PRP obtained 1 hour after ingestion of 650 mg or 1000 mg APAP, arachidonate-induced TxB2 formation was inhibited by 40-99% in five subjects tested, whereas inhibition of collagen- or epinephrine-induced TxB2 formation was less consistent.

Negative_regulation (inhibited) of TxB2 in PRP associated with paracetamol

6) Confidence 0.02 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 1.01

In contrast to aspirin and indomethacin, APAP-induced inhibition of collagen-stimulated TxB2 formation could be partially overcome with increasing collagen concentrations.

Negative_regulation (inhibition) of TxB2 associated with aspirin and paracetamol

7) Confidence 0.02 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 1.16

APAP added in vitro to citrated platelet-rich plasma (PRP) inhibited aggregation, secretion, and TxB2 formation induced by collagen, epinephrine, arachidonate, and the ionophore A23187, but had no effect on the responses induced by the endoperoxide analog U44069.

Negative_regulation (inhibited) of TxB2 in plasma associated with paracetamol

8) Confidence 0.02 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 0.74

In PRP obtained 1 hour after ingestion of 650 mg or 1000 mg APAP, arachidonate-induced TxB2 formation was inhibited by 40-99% in five subjects tested, whereas inhibition of collagen- or epinephrine-induced TxB2 formation was less consistent.

Negative_regulation (inhibition) of TxB2 in PRP associated with paracetamol

9) Confidence 0.02 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 1.08

In washed platelet suspensions labeled with 3H-arachidonate, both APAP and aspirin inhibited the formation of labeled PGD2 and PGE2, as well as TxB2.

Negative_regulation (inhibited) of TxB2 in platelet associated with aspirin and paracetamol

10) Confidence 0.02 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 1.02

General Comments

This test has worked.