INT2512

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 10.15
Pain Relevance 8.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cp) oxidoreductase activity (Cp) aging (Cp)
extracellular region (Cp)
Anatomy Link Frequency
bone marrow 2
neurons 2
embryos 1
plasma 1
liver 1
Cp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 23 100.00 Very High Very High Very High
analgesia 20 100.00 Very High Very High Very High
qutenza 13 100.00 Very High Very High Very High
ketamine 10 100.00 Very High Very High Very High
Morphine 21 99.72 Very High Very High Very High
Analgesic 4 99.70 Very High Very High Very High
methadone 3 98.80 Very High Very High Very High
Opioid 4 98.08 Very High Very High Very High
tail-flick 2 97.36 Very High Very High Very High
cerebral cortex 10 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cerebral Palsy 42 100.00 Very High Very High Very High
Pancreatitis 38 100.00 Very High Very High Very High
Toxicity 11 99.64 Very High Very High Very High
Impaired Glucose Tolerance 3 98.84 Very High Very High Very High
Osteoporosis 4 98.64 Very High Very High Very High
Acute Liver Failure 9 98.32 Very High Very High Very High
Liver Disease 7 98.10 Very High Very High Very High
Diarrhoea 3 98.04 Very High Very High Very High
Neutropenia 2 97.92 Very High Very High Very High
Arrhythmia Under Development 2 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, neuronal counting showed that cell proliferation in the CP was suppressed after morphine administration and that the migration of neurons from the matrix zone (MZ) to the cortex was decelerated.
Negative_regulation (suppressed) of CP in neurons associated with morphine
1) Confidence 0.51 Published 2008 Journal Brain Res. Section Abstract Doc Link 18848821 Disease Relevance 0.14 Pain Relevance 0.84
Histomorphometric evaluation revealed that the thickness of the CP was significantly decreased in the morphine-exposed embryos.
Negative_regulation (decreased) of CP in embryos associated with morphine
2) Confidence 0.51 Published 2008 Journal Brain Res. Section Abstract Doc Link 18848821 Disease Relevance 0.15 Pain Relevance 0.86
The differences between brain regions with the highest and the lowest PMSF-inhibited CP activity do not exceed 1.5 fold.
Negative_regulation (inhibited) of CP in brain
3) Confidence 0.50 Published 1997 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 9505357 Disease Relevance 0 Pain Relevance 0.07
In the brain region the lowest PMSF-inhibited CP activity was observed in hippocamp and optic and auditory hills, the highest enzyme activity, in the olfactory bulbus and cerebral hemispheres.
Negative_regulation (inhibited) of CP in olfactory
4) Confidence 0.50 Published 1997 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 9505357 Disease Relevance 0 Pain Relevance 0.08
A post hoc simulation showed that the Cp Alfref decreased the predicted Cp Alf compared with mean arterial blood pressure alone.
Negative_regulation (decreased) of Cp in blood
5) Confidence 0.44 Published 2006 Journal Anesthesiology Section Body Doc Link 16931977 Disease Relevance 0 Pain Relevance 0
Thus the present studies suggest that CP is indeed analgesic and that this effect of CP is mediated by neither movement inhibition nor distraction.
Negative_regulation (effect) of CP associated with analgesic
6) Confidence 0.43 Published 1979 Journal J Comp Physiol Psychol Section Abstract Doc Link 457954 Disease Relevance 0.43 Pain Relevance 0.17
In animals chronically preexposed to 14 daily swims, CP analgesia was reduced and CWS analgesia was reduced at 60, but not 30 min after the swim.
Negative_regulation (reduced) of CP associated with analgesia
7) Confidence 0.38 Published 1984 Journal Physiol. Behav. Section Abstract Doc Link 6091163 Disease Relevance 0 Pain Relevance 0.94
The present study examined whether CP analgesia, like CWS analgesia, would be reduced by prior repeated CWS exposure.
Negative_regulation (reduced) of CP associated with analgesia
8) Confidence 0.38 Published 1984 Journal Physiol. Behav. Section Abstract Doc Link 6091163 Disease Relevance 0 Pain Relevance 0.90
The objectives of the study were to compare the diagnostic yield and accuracy of EUS-guided FNA (EUS-FNA) in the evaluation of pancreatic-mass lesions in the presence or the absence of CP and to identify predictors of CP before EUS-FNA of pancreatic-mass lesions.
Negative_regulation (absence) of CP associated with chronic pancreatitis
9) Confidence 0.37 Published 2005 Journal Gastrointest. Endosc. Section Abstract Doc Link 16246688 Disease Relevance 0.46 Pain Relevance 0.46
Ag injection notably decreased the activity of serum CP in the Fischer rats, but not in the LEC rats.
Negative_regulation (decreased) of CP
10) Confidence 0.37 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10959791 Disease Relevance 0 Pain Relevance 0.14
The controller adjusted the alfentanil infusion rate to maintain the mean arterial blood pressure near the set-point (70 mmHg) while minimizing the Cp Alf toward the set-point plasma alfentanil concentration (Cp Alfref) (100 ng/ml).
Negative_regulation (minimizing) of Cp in plasma
11) Confidence 0.32 Published 2006 Journal Anesthesiology Section Body Doc Link 16931977 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: We conclude that preprocedural seropositivity of CP IgA is a risk factor for MACE and angina pectoris after PCI.
Negative_regulation (preprocedural) of CP
12) Confidence 0.29 Published 2004 Journal Am. Heart J. Section Body Doc Link 15459599 Disease Relevance 0 Pain Relevance 0
In comparison with control group, the degranulation ratios (DGR) of mast cells in MA and EA groups increased significantly (P < 0.05); while compared with MA and EA groups separately, DGR of the corresponding CP + MA and DSCP + MA, and CP + EA and DSCP + EA groups decreased markedly (P < 0.05), displaying an inhibition of mast cell degranulation following CP and DSCP in ST36 area.
Negative_regulation (inhibition) of CP in mast cell
13) Confidence 0.28 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 19097502 Disease Relevance 0 Pain Relevance 0
Both Cp and Ck decreased quickly after the end of infusions.
Negative_regulation (decreased) of Cp associated with ketamine
14) Confidence 0.28 Published 1998 Journal Masui Section Abstract Doc Link 9560543 Disease Relevance 0.09 Pain Relevance 0.52
Similar change patterns of the permeation parameters were also observed in the hydrogels, but the J(s) of CP was reduced significantly along with the increasing concentration of Carbopol U21.
Negative_regulation (reduced) of CP associated with qutenza
15) Confidence 0.25 Published 2008 Journal Int J Pharm Section Abstract Doc Link 18417302 Disease Relevance 0 Pain Relevance 0.84
Substituting LiCl for NaCl or increasing the K+ content in the medium decreased CP uptake.
Negative_regulation (decreased) of CP
16) Confidence 0.25 Published 1980 Journal Toxicology Section Abstract Doc Link 7414614 Disease Relevance 0 Pain Relevance 0.17
Chloroamphetamine, desimipramine, imipramine, morphine, chlorpromazine, dieldrin, methadone, amphetamine (each at 1 mM) and incubation at 10 degrees C inhibited CP uptake.
Negative_regulation (inhibited) of CP associated with methadone and morphine
17) Confidence 0.25 Published 1980 Journal Toxicology Section Abstract Doc Link 7414614 Disease Relevance 0.06 Pain Relevance 0.20
Incubation of slices with Na+-pump inhibitors, harmaline and iodoacetate, significantly decreased CP uptake.
Negative_regulation (decreased) of CP
18) Confidence 0.25 Published 1980 Journal Toxicology Section Abstract Doc Link 7414614 Disease Relevance 0 Pain Relevance 0.19
In conclusion, the results indicate that neuronal replacement can be achieved by cross-species implantation of fetal striatal precursor cells to the previously neuron depleted primate CP under immunosuppression but that the survival and growth of such implants may be variable and subject to unfavourable trophic conditions.
Negative_regulation (depleted) of CP in neuron
19) Confidence 0.19 Published 1989 Journal Exp Brain Res Section Abstract Doc Link 2523313 Disease Relevance 0.07 Pain Relevance 0.08
The results indicated that treatment of rats within a select dose range of SLM could reduce CP-induced toxicity on blood cells and bone marrow.
Negative_regulation (reduce) of CP in blood cells associated with toxicity
20) Confidence 0.16 Published 2009 Journal Drug Chem Toxicol Section Abstract Doc Link 19793036 Disease Relevance 0.24 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox